Nectin 2 Antibody (502-57): sc-52708
- Nectin 2 Antibody (502-57) is a rat monoclonal IgG2a provided at 100 µg/ml
- raised against the extracellular domain of Nectin 2 of mouse origin
- recommended for detection of Nectin 2 of mouse, rat and human origin by WB, IP, IF and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nectin 2 Antibody (502-57). This work is in progress.
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Nectin 2 Antibody (502-57) is a rat monoclonal IgG2a antibody that detects Nectin 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Nectin 2 is a crucial member of the nectin family, which plays a significant role in cell adhesion and communication, particularly in the nervous system and immune response. Nectin 2 is primarily located at the cell membrane, where anti-Nectin 2 antibody (502-57) can detect homophilic interactions between adjacent cells, contributing to the formation of tight junctions and maintenance of tissue integrity. Nectin 2′s location is significant due to involvement in mediating the entry of certain herpesviruses, such as herpes simplex virus type 2 and pseudorabies virus, into host cells, which can have significant implications for viral pathogenesis and infection dynamics. Additionally, Nectin 2 exists in two splicing variants, Nectin 2α and Nectin 2δ, both sharing identical extracellular regions but differing in transmembrane and cytoplasmic domains. Notably, Nectin 2δ undergoes tyrosine phosphorylation in response to cell-cell adhesion, a modification that may influence interactions with the cytoskeleton and signaling pathways. Nectin 2 monoclonal antibody (502-57) serves as an essential tool for researchers studying cell adhesion mechanisms, viral entry processes, and functional roles of nectins in various biological contexts.
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Nectin 2 Antibody (502-57) References:
- Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers. | Oshima, T., et al. 2013. Mol Cancer. 12: 60. PMID: 23758976
- Serum nectin-2 levels are diagnostic and prognostic in patients with colorectal carcinoma. | Karabulut, M., et al. 2016. Clin Transl Oncol. 18: 160-71. PMID: 26184725
- The Clinical and Pathological Significance of Nectin-2 and DDX3 Expression in Pancreatic Ductal Adenocarcinomas. | Liang, S., et al. 2015. Dis Markers. 2015: 379568. PMID: 26294807
- Elevated Nectin-2 expression is involved in esophageal squamous cell carcinoma by promoting cell migration and invasion. | Li, M., et al. 2018. Oncol Lett. 15: 4731-4736. PMID: 29552112
- The Ubiquitin-proteasome pathway regulates Nectin2/CD112 expression and impairs NK cell recognition and killing. | Molfetta, R., et al. 2019. Eur J Immunol. 49: 873-883. PMID: 30888046
- Lipid-related protein NECTIN2 is an important marker in the progression of carotid atherosclerosis: An intersection of clinical and basic studies. | Li, S., et al. 2021. J Transl Int Med. 9: 294-306. PMID: 35136728
- Extracellular CIRP Induces Novel Nectin-2+ (CD112+) Neutrophils to Promote Th1 Differentiation in Sepsis. | Murata, K., et al. 2023. J Immunol. 210: 310-321. PMID: 36480269
- Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma. | Zhang, S., et al. 2023. Acta Biochim Biophys Sin (Shanghai). 55: 356-366. PMID: 36916296
- N6-methyladenosine-associated genetic variants in NECTIN2 and HPCAL1 are risk factors for abdominal aortic aneurysm. | Li, T., et al. 2024. iScience. 27: 109419. PMID: 38510151
- NECTIN2 is a prognostic biomarker and potential therapeutic target in lung adenocarcinoma. | Ando, T., et al. 2024. Respir Investig. 62: 582-588. PMID: 38678829
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nectin 2 Antibody (502-57) | sc-52708 | 100 µg/ml | $322.00 |