NDV HN Antibody (HN4a): sc-53561

NDV HN Antibody (HN4a) is a mouse monoclonal IgG2a antibody that detects NDV HN of Newcastle disease virus by immunoprecipitation (IP) and immunofluorescence (IF) applications. NDV HN, or hemagglutinin neuraminidase, plays a crucial role in the viral life cycle as it is responsible for the binding of the Newcastle disease virus to host cells. NDV HN (HN4a) antibody recognizes a protein located on the external envelope of the virus that is glycosylated, which is essential for interaction with sialic acid-containing receptors on the surface of target cells. The binding of NDV HN to these receptors not only facilitates viral entry but also triggers an upregulation of important host cell proteins, including TRAIL and death receptors, as well as interferon-alpha, which are critical for the host′s immune response. The fusion of viral and cell membranes, a process regulated by the NDV F protein, is also initiated by this interaction, allowing the virus to infect neighboring cells and enhance virulence. NDV HN monoclonal antibody (HN4a) serves as an invaluable tool for studying the mechanisms of Newcastle disease virus infection and the host′s response, providing insights into viral pathogenesis and potential therapeutic targets.

The preferred NDV HN antibody is NDV HN Antibody (HN14f): sc-53562.