NDV HN Antibody (HN14f): sc-53562
- NDV HN Antibody (HN14f) is a mouse monoclonal IgG2a κ NDV HN antibody, cited in 9 publications, provided at 200 µg/ml
- raised against HN of Austrailia-Victoria (AV-WT) strain of Newcastle disease virus virus origin
- NDV HN Antibody (HN14f) is recommended for detection of hemagglutinin neuramidase of Australia-Victoria strain of Newcastle disease virus origin by IP and IF
- Anti-NDV HN Antibody (HN14f) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for NDV HN Antibody (HN14f). These reagents are now offered in bundles with NDV HN Antibody (HN14f) (see ordering information below).
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NDV HN Antibody (HN14f) is a mouse monoclonal IgG2a kappa light chain antibody that detects the NDV HN protein of Newcastle disease virus origin by immunoprecipitation (IP) and immunofluorescence (IF). NDV HN (HN14f) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Newcastle disease virus (NDV) is a negative-sense single-stranded RNA virus responsible for Newcastle disease, a highly contagious zoonotic disease that affects numerous domestic and wild avian species. The NDV HN protein, which is glycosylated, plays a crucial role in virus′s ability to infect host cells by binding to sialic acid-containing receptors on the cell surface. This interaction not only facilitates viral entry but also triggers an upregulation of host cell expression of important immune mediators such as TRAIL and death receptors, as well as interferon-alpha. The fusion of viral and host cell membranes, a process regulated by the NDV F protein, is essential for the spread of the virus to neighboring cells, thereby enhancing infectivity and virulence. Understanding the function of NDV HN protein is vital for developing effective strategies to control and prevent Newcastle disease in avian populations.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NDV HN Antibody (HN14f) References:
- Newcastle disease virus isolated from recent outbreaks in Taiwan phylogenetically related to viruses (genotype VII) from recent outbreaks in western Europe. | Yang, CY., et al. 1999. Avian Dis. 43: 125-30. PMID: 10216769
- Newcastle disease virus (NDV): brief history of its oncolytic strains. | Sinkovics, JG. and Horvath, JC. 2000. J Clin Virol. 16: 1-15. PMID: 10680736
- Newcastle disease and other avian paramyxoviruses. | Alexander, DJ. 2000. Rev Sci Tech. 19: 443-62. PMID: 10935273
- The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion. | Chen, L., et al. 2001. Structure. 9: 255-66. PMID: 11286892
- Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus. | Yu, M., et al. 2002. J Gen Virol. 83: 623-629. PMID: 11842257
- HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells. | Ravindra, PV., et al. 2008. Arch Virol. 153: 749-54. PMID: 18288442
- Quantitative basic residue requirements in the cleavage-activation site of the fusion glycoprotein as a determinant of virulence for Newcastle disease virus. | Glickman, RL., et al. 1988. J Virol. 62: 354-6. PMID: 3275436
- Structural comparison of the cleavage-activation site of the fusion glycoprotein between virulent and avirulent strains of Newcastle disease virus. | Toyoda, T., et al. 1987. Virology. 158: 242-7. PMID: 3576973
- Transcriptive complex of Newcastle disease virus. I. Both L and P proteins are required to constitute an active complex. | Hamaguchi, M., et al. 1983. Virology. 128: 105-17. PMID: 6683907
- Complete nucleotide sequence of Newcastle disease virus: evidence for the existence of a new genus within the subfamily Paramyxovirinae. | de Leeuw, O. and Peeters, B. 1999. J Gen Virol. 80 (Pt 1): 131-136. PMID: 9934695
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDV HN Antibody (HN14f) | sc-53562 | 200 µg/ml | $322.00 | |||
NDV HN Antibody (HN14f): m-IgG Fc BP-HRP Bundle | sc-525607 | 200 µg Ab; 10 µg BP | $361.00 | |||
NDV HN Antibody (HN14f): m-IgG2a BP-HRP Bundle | sc-546337 | 200 µg Ab; 10 µg BP | $361.00 | |||
NDV HN Antibody (HN14f) AC | sc-53562 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NDV HN Antibody (HN14f) HRP | sc-53562 HRP | 200 µg/ml | $322.00 | |||
NDV HN Antibody (HN14f) FITC | sc-53562 FITC | 200 µg/ml | $336.00 | |||
NDV HN Antibody (HN14f) PE | sc-53562 PE | 200 µg/ml | $349.00 | |||
NDV HN Antibody (HN14f) Alexa Fluor® 488 | sc-53562 AF488 | 200 µg/ml | $364.00 | |||
NDV HN Antibody (HN14f) Alexa Fluor® 546 | sc-53562 AF546 | 200 µg/ml | $364.00 | |||
NDV HN Antibody (HN14f) Alexa Fluor® 594 | sc-53562 AF594 | 200 µg/ml | $364.00 | |||
NDV HN Antibody (HN14f) Alexa Fluor® 647 | sc-53562 AF647 | 200 µg/ml | $364.00 | |||
NDV HN Antibody (HN14f) Alexa Fluor® 680 | sc-53562 AF680 | 200 µg/ml | $364.00 | |||
NDV HN Antibody (HN14f) Alexa Fluor® 790 | sc-53562 AF790 | 200 µg/ml | $364.00 |