NDUFV2 Antibody (F-5): sc-271620
- NDUFV2 Antibody (F-5) is a mouse monoclonal IgG2a κ NDUFV2 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-249 representing full length NDUFV2 of human origin
- NDUFV2 Antibody (F-5) is recommended for detection of NDUFV2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-NDUFV2 Antibody (F-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NDUFV2 Antibody (F-5) for WB and IHC(P) applications. These reagents are now offered in bundles with NDUFV2 Antibody (F-5) (see ordering information below).
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NDUFV2 Antibody (F-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects NDUFV2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NDUFV2 (F-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NDUFV2 protein, also known as NADH dehydrogenase [ubiquinone] flavoprotein 2, is a crucial component of mitochondrial complex I, which is located in the mitochondrial inner membrane. This complex plays a vital role in the electron transport chain of oxidative phosphorylation, where NDUFV2 catalyzes the oxidation of NADH produced in the Krebs cycle, reducing ubiquinone to ubiquinol and facilitating the transfer of electrons through the chain, ultimately leading to the reduction of oxygen to water. NDUFV2′s structure, comprising 249 amino acids, is essential for the catalytic activity of complex I, and any defects in NDUFV2 can result in significant clinical implications, including various myopathies and neuropathies. Research has indicated that genetic polymorphisms in the NDUFV2 gene may contribute to the risk of developing bipolar disorder and schizophrenia, highlighting NDUFV2′s importance in both cellular function and potential psychiatric conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NDUFV2 Antibody (F-5) References:
- Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. | Washizuka, S., et al. 2003. Am J Med Genet B Neuropsychiatr Genet. 120B: 72-8. PMID: 12815743
- Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with schizophrenia in the Japanese population. | Washizuka, S., et al. 2006. Am J Med Genet B Neuropsychiatr Genet. 141B: 301-4. PMID: 16508936
- Sp1 expression is disrupted in schizophrenia; a possible mechanism for the abnormal expression of mitochondrial complex I genes, NDUFV1 and NDUFV2. | Ben-Shachar, D. and Karry, R. 2007. PLoS One. 2: e817. PMID: 17786189
- Further support for association of the mitochondrial complex I subunit gene NDUFV2 with bipolar disorder. | Xu, C., et al. 2008. Bipolar Disord. 10: 105-10. PMID: 18199248
- Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression. | Ben-Shachar, D. and Karry, R. 2008. PLoS One. 3: e3676. PMID: 18989376
- Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. | Washizuka, S., et al. 2009. Neurosci Res. 63: 199-204. PMID: 19135101
- Association study on the mitochondrial gene NDUFV2 and bipolar disorder in the Chinese Han population. | Zhang, J., et al. 2009. J Neural Transm (Vienna). 116: 357-61. PMID: 19194776
- Mitochondrial NADH-ubiquinone reductase: complementary DNA sequences of import precursors of the bovine and human 24-kDa subunit. | Pilkington, SJ. and Walker, JE. 1989. Biochemistry. 28: 3257-64. PMID: 2500970
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDUFV2 Antibody (F-5) | sc-271620 | 200 µg/ml | $322.00 | |||
NDUFV2 Antibody (F-5): m-IgG Fc BP-HRP Bundle | sc-529223 | 200 µg Ab; 10 µg BP | $361.00 | |||
NDUFV2 Antibody (F-5): m-IgGκ BP-HRP Bundle | sc-521999 | 200 µg Ab, 40 µg BP | $361.00 | |||
NDUFV2 Antibody (F-5) AC | sc-271620 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NDUFV2 Antibody (F-5) HRP | sc-271620 HRP | 200 µg/ml | $322.00 | |||
NDUFV2 Antibody (F-5) FITC | sc-271620 FITC | 200 µg/ml | $336.00 | |||
NDUFV2 Antibody (F-5) PE | sc-271620 PE | 200 µg/ml | $349.00 | |||
NDUFV2 Antibody (F-5) Alexa Fluor® 488 | sc-271620 AF488 | 200 µg/ml | $364.00 | |||
NDUFV2 Antibody (F-5) Alexa Fluor® 546 | sc-271620 AF546 | 200 µg/ml | $364.00 | |||
NDUFV2 Antibody (F-5) Alexa Fluor® 594 | sc-271620 AF594 | 200 µg/ml | $364.00 | |||
NDUFV2 Antibody (F-5) Alexa Fluor® 647 | sc-271620 AF647 | 200 µg/ml | $364.00 | |||
NDUFV2 Antibody (F-5) Alexa Fluor® 680 | sc-271620 AF680 | 200 µg/ml | $364.00 | |||
NDUFV2 Antibody (F-5) Alexa Fluor® 790 | sc-271620 AF790 | 200 µg/ml | $364.00 |