NDUFV2 Antibody (B-11): sc-515589

NDUFV2 Antibody (B-11) is a mouse monoclonal IgG1 antibody that detects NDUFV2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NDUFV2, also known as NADH-ubiquinone oxidoreductase 24 kDa subunit, is a crucial component of mitochondrial complex I, the largest enzyme in the electron transport chain responsible for oxidative phosphorylation. This 249 amino acid protein plays a vital role in the catalytic activity of the complex, facilitating the conversion of NADH, produced during the Krebs cycle, into ubiquinol, which is essential for the efficient transfer of electrons through the mitochondrial respiratory chain. Proper functioning of NDUFV2 is critical, as defects in any of the subunits of mitochondrial complex I can lead to severe myopathies and neuropathies, highlighting NDUFV2′s importance in cellular energy metabolism. Furthermore, emerging research indicates that genetic polymorphisms in the NDUFV2 gene may contribute to the risk of developing psychiatric disorders such as bipolar disorder and schizophrenia, underscoring NDUFV2′s relevance not only in mitochondrial function but also in neurobiology. Anti-NDUFV2 antibody (B-11) is an invaluable tool for researchers investigating the intricate roles of mitochondrial function and its implications in health and disease.

The preferred NDUFV2 antibody is NDUFV2 Antibody (F-5): sc-271620.