NDUFS2 Antibody (B-3): sc-390596
- NDUFS2 Antibody (B-3) is a mouse monoclonal IgG1 κ NDUFS2 antibody, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 101-344 mapping within an internal region of NDUFS2 of human origin
- NDUFS2 Antibody (B-3) is recommended for detection of NDUFS2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-NDUFS2 Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NDUFS2 Antibody (B-3) for WB and IHC(P) applications. These reagents are now offered in bundles with NDUFS2 Antibody (B-3) (see ordering information below).
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NDUFS2 Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects NDUFS2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-NDUFS2 antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NDUFS2, or NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, is a crucial subunit of mitochondrial complex I, which is located in the mitochondrial inner membrane and plays a vital role in the electron transport chain of oxidative phosphorylation. This complex is responsible for the initial step of cellular respiration, where NDUFS2 oxidizes NADH produced in the Krebs cycle, transferring electrons to ubiquinone and ultimately facilitating the reduction of oxygen to water. The structure of NDUFS2, comprising 463 amino acids, is essential for catalytic activity, and defects in NDUFS2 can lead to severe clinical manifestations, including complex I mitochondrial respiratory chain deficiency, which is associated with conditions such as liver failure, cardiomyopathy, and neurodegeneration. The significance of NDUFS2 in maintaining mitochondrial function underscores NDUFS2′s relevance in both basic research and clinical diagnostics, making NDUFS2 (B-3) monoclonal antibody an invaluable tool for studying mitochondrial disorders and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NDUFS2 Antibody (B-3) References:
- Human mitochondrial complex I in health and disease. | Smeitink, J. and van den Heuvel, L. 1999. Am J Hum Genet. 64: 1505-10. PMID: 10330338
- Mutations in the complex I NDUFS2 gene of patients with cardiomyopathy and encephalomyopathy. | Loeffen, J., et al. 2001. Ann Neurol. 49: 195-201. PMID: 11220739
- Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency. | Ugalde, C., et al. 2004. Hum Mol Genet. 13: 659-67. PMID: 14749350
- Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency. | Visch, HJ., et al. 2004. J Biol Chem. 279: 40328-36. PMID: 15269216
- Clinical and molecular findings in children with complex I deficiency. | Bugiani, M., et al. 2004. Biochim Biophys Acta. 1659: 136-47. PMID: 15576045
- Analysis of the assembly profiles for mitochondrial- and nuclear-DNA-encoded subunits into complex I. | Lazarou, M., et al. 2007. Mol Cell Biol. 27: 4228-37. PMID: 17438127
- Mapping to 1q23 of the human gene (NDUFS2) encoding the 49-kDa subunit of the mitochondrial respiratory Complex I and immunodetection of the mature protein in mitochondria. | Procaccio, V., et al. 1998. Mamm Genome. 9: 482-4. PMID: 9585441
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDUFS2 Antibody (B-3) | sc-390596 | 200 µg/ml | $322.00 | |||
NDUFS2 Antibody (B-3): m-IgG Fc BP-HRP Bundle | sc-530198 | 200 µg Ab; 10 µg BP | $361.00 | |||
NDUFS2 Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-523596 | 200 µg Ab, 40 µg BP | $361.00 | |||
NDUFS2 Antibody (B-3): m-IgG1 BP-HRP Bundle | sc-543922 | 200 µg Ab; 20 µg BP | $361.00 | |||
NDUFS2 Antibody (B-3) AC | sc-390596 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NDUFS2 Antibody (B-3) HRP | sc-390596 HRP | 200 µg/ml | $322.00 | |||
NDUFS2 Antibody (B-3) FITC | sc-390596 FITC | 200 µg/ml | $336.00 | |||
NDUFS2 Antibody (B-3) PE | sc-390596 PE | 200 µg/ml | $349.00 | |||
NDUFS2 Antibody (B-3) Alexa Fluor® 488 | sc-390596 AF488 | 200 µg/ml | $364.00 | |||
NDUFS2 Antibody (B-3) Alexa Fluor® 546 | sc-390596 AF546 | 200 µg/ml | $364.00 | |||
NDUFS2 Antibody (B-3) Alexa Fluor® 594 | sc-390596 AF594 | 200 µg/ml | $364.00 | |||
NDUFS2 Antibody (B-3) Alexa Fluor® 647 | sc-390596 AF647 | 200 µg/ml | $364.00 | |||
NDUFS2 Antibody (B-3) Alexa Fluor® 680 | sc-390596 AF680 | 200 µg/ml | $364.00 | |||
NDUFS2 Antibody (B-3) Alexa Fluor® 790 | sc-390596 AF790 | 200 µg/ml | $364.00 |