NCoA-3 Antibody (0.T.198): sc-56854

NCoA-3 Antibody (0.T.198) is a mouse monoclonal IgG1 antibody that detects NCoA-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). NCoA-3, also known as RAC3, ACTR, AIB-1, and p/CIP, plays a crucial role as a transcriptional coactivator that interacts with steroid hormone receptors, thereby influencing gene expression in response to hormonal signals. NCoA-3 is particularly significant in cancer biology, showing overexpression in estrogen receptor-positive ovarian and breast cancers, contributing to the transcriptional activation of p300/CBP-dependent transcription factors. NCoA-3′s ability to modulate transcriptional activity highlights its importance in regulating genes involved in cell proliferation and survival, making NCoA-3 a key player in the development and progression of hormone-responsive tumors. Anti-NCoA-3 antibody (0.T.198) enables researchers to gain valuable insights into hormone action mechanisms and coactivator roles in cancer, facilitating the exploration of potential therapeutic targets.

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NCoA-3 Antibody (0.T.198) References:

1. Detection of antisense and ribozyme accessible sites on native mRNAs: application to NCOA3 mRNA.  |  Scherr, M., et al. 2001. Mol Ther. 4: 454-60. PMID: 11708882
2. Characterization of two candidate genes, NCoA3 and IRF8, potentially involved in the control of HIV-1 latency.  |  Munier, S., et al. 2005. Retrovirology. 2: 73. PMID: 16305739
3. The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival.  |  Chen, X., et al. 2010. Mol Endocrinol. 24: 1917-34. PMID: 20685850
4. SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein.  |  Sun, Y., et al. 2011. J Biol Chem. 286: 18623-32. PMID: 21454665
5. Lysine residues 639 and 673 of mouse Ncoa3 are ubiquitination sites for the regulation of its stability.  |  Mou, C., et al. 2014. Acta Biochim Biophys Sin (Shanghai). 46: 1066-71. PMID: 25348736
6. Correlation of the osteoarthritis susceptibility variants that map to chromosome 20q13 with an expression quantitative trait locus operating on NCOA3 and with functional variation at the polymorphism rs116855380.  |  Gee, F., et al. 2015. Arthritis Rheumatol. 67: 2923-32. PMID: 26211391
7. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis.  |  Wang, Y., et al. 2016. Biomaterials. 101: 108-120. PMID: 27267632
8. Non-Syndromic Autosomal Dominant Hearing Loss: The First Italian Family Carrying a Mutation in the NCOA3 Gene.  |  Tesolin, P., et al. 2021. Genes (Basel). 12: PMID: 34356059
9. A case of spindle cell rhabdomyosarcoma with a ZFP64::NCOA3 fusion.  |  Yoshida, KI., et al. 2024. Genes Chromosomes Cancer. 63: e23212. PMID: 37905771
10. Evaluation of the diagnostic utility of NCOA3, Maspin and VHL protein expression in pancreatic ductal adenocarcinoma: An immunohistochemical study.  |  Elkady, N., et al. 2024. Ann Diagn Pathol. 73: 152356. PMID: 38901088

The preferred NCoA-3 antibody is NCoA-3 Antibody (F-2): sc-5305.