NCAM-L1 Antibody (C-2): sc-514360

NCAM-L1 Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects NCAM-L1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-NCAM-L1 antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NCAM-L1, also known as CD171, is a crucial cell adhesion molecule that plays a significant role in axon guidance and cell migration within the nervous system. NCAM-L1 expression is vital for proper neuronal development and function, facilitating interactions between neurons and their environment, influencing processes such as synaptic plasticity and neural network formation. NCAM-L1 is also implicated in various human tumors, including neuroblastomas and rhabdomyosarcomas, where NCAM-L1 may enhance tumor progression by promoting cell adhesion and migration. NCAM-L1′s presence in these malignancies underscores NCAM-L1′s potential as a biomarker for cancer diagnosis and a target for therapeutic intervention, making NCAM-L1 monoclonal antibody (C-2) an essential tool for researchers studying both normal neuronal development and cancer biology.

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NCAM-L1 Antibody (C-2) References:

1. Missense mutations in the extracellular domain of the human neural cell adhesion molecule L1 reduce neurite outgrowth of murine cerebellar neurons.  |  Michelson, P., et al. 2002. Hum Mutat. 20: 481-2. PMID: 12442287
2. Generation of affinity matured scFv antibodies against mouse neural cell adhesion molecule L1 by phage display.  |  Dong, L., et al. 2003. Biochem Biophys Res Commun. 301: 60-70. PMID: 12535641
3. Water maze learning and forebrain mRNA expression of the neural cell adhesion molecule L1.  |  Venero, C., et al. 2004. J Neurosci Res. 75: 172-181. PMID: 14705138
4. Neural cell adhesion molecule L1 is required for fasciculation and routing of thalamocortical fibres and corticothalamic fibres.  |  Ohyama, K., et al. 2004. Neurosci Res. 48: 471-5. PMID: 15041201
5. Pathological missense mutations of neural cell adhesion molecule L1 affect neurite outgrowth and branching on an L1 substrate.  |  Cheng, L. and Lemmon, V. 2004. Mol Cell Neurosci. 27: 522-30. PMID: 15555929
6. Rabex-5 protein regulates the endocytic trafficking pathway of ubiquitinated neural cell adhesion molecule L1.  |  Aikawa, Y. 2012. J Biol Chem. 287: 32312-23. PMID: 22846990
7. A Fab fragment directed against the neural cell adhesion molecule L1 enhances functional recovery after injury of the adult mouse spinal cord.  |  Loers, G., et al. 2014. Biochem J. 460: 437-46. PMID: 24673421
8. Expression and serum levels of the neural cell adhesion molecule L1-like protein (CHL1) in gastrointestinal stroma tumors (GIST) and its prognostic power.  |  Karstens, KF., et al. 2020. Oncotarget. 11: 1131-1140. PMID: 32284790
9. New domains of neural cell-adhesion molecule L1 implicated in X-linked hydrocephalus and MASA syndrome.  |  Jouet, M., et al. 1995. Am J Hum Genet. 56: 1304-14. PMID: 7762552
10. Casein kinase II phosphorylates the neural cell adhesion molecule L1.  |  Wong, EV., et al. 1996. J Neurochem. 66: 779-86. PMID: 8592152

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NCAM-L1 Antibody (C-2) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-NCAM-L1 Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NCAM-L1 Antibody (C-2) Specifications

Alternate Product Name: L1CAM

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1231-1258

Epitope Target: NCAM-L1

Epitope Species: human

Product Reactivity/Detection: NCAM-L1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for NCAM-L1 Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred NCAM-L1 antibody is NCAM-L1 Antibody (UJ127.11): sc-53386.