NCAM/CD56 Antibody (123C3): sc-7326

NCAM Antibody (123C3) is a mouse monoclonal IgG1 kappa light chain antibody that specifically targets Neural Cell Adhesion Molecule 1 (NCAM1), also known as CD56, a critical cell surface glycoprotein located on the plasma membrane of neural cells. This strategic localization enables NCAM1 to facilitate essential cell-cell interactions during embryonic development and maintain neural network integrity in adult tissues. Anti-NCAM1 antibody (123C3) effectively detects NCAM1 proteins from mouse, rat, and human origins across various applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). NCAM1 monoclonal antibody (123C3) is particularly recommended for identifying neuroectodermally derived tumors such as neuroblastoma, medulloblastoma, astrocytoma, and retinoblastoma, highlighting NCAM1′s significance in tumor biology. Available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® variants, NCAM1 (123C3) antibody provides versatile options for researchers studying cell adhesion, neural development, and related pathologies. Additionally, anti-NCAM1 antibody (123C3) recognizes multiple isoforms of NCAM1 that arise from alternative splicing and polyadenylation, thereby enhancing its utility across diverse experimental models. Whether used in basic research or clinical diagnostics, NCAM1 (123C3) monoclonal antibody serves as an indispensable tool for advancing our understanding of neural cell interactions and associated diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

NCAM/CD56 Antibody (123C3) References:

1. NCAM mimetic peptides: Pharmacological and therapeutic potential.  |  Berezin, V. and Bock, E. 2004. J Mol Neurosci. 22: 33-39. PMID: 14742908
2. Zippers make signals: NCAM-mediated molecular interactions and signal transduction.  |  Walmod, PS., et al. 2004. Neurochem Res. 29: 2015-35. PMID: 15662836
3. Structural biology of NCAM homophilic binding and activation of FGFR.  |  Kiselyov, VV., et al. 2005. J Neurochem. 94: 1169-79. PMID: 16045455
4. NCAM-induced intracellular signaling revisited.  |  Ditlevsen, DK., et al. 2008. J Neurosci Res. 86: 727-43. PMID: 17975827
5. NCAM and the FGF-receptor.  |  Kiselyov, VV. 2010. Adv Exp Med Biol. 663: 67-79. PMID: 20017015
6. Biosynthesis of NCAM.  |  Kolkova, K. 2010. Adv Exp Med Biol. 663: 213-25. PMID: 20017025
7. NCAM in long-term potentiation and learning.  |  Hartz, BP. and Rønn, LC. 2010. Adv Exp Med Biol. 663: 257-70. PMID: 20017028
8. A Possible Modulation Mechanism of Intramolecular and Intermolecular Interactions for NCAM Polysialylation and Cell Migration.  |  Lu, B., et al. 2019. Curr Top Med Chem. 19: 2271-2282. PMID: 31648641
9. Ubiquitous Neural Cell Adhesion Molecule (NCAM): Potential Mechanism and Valorisation in Cancer Pathophysiology, Drug Targeting and Molecular Transductions.  |  Sowparani, S., et al. 2022. Mol Neurobiol. 59: 5902-5924. PMID: 35831555
10. CD56/NCAM mediates cell migration of human NK cells by promoting integrin-mediated adhesion turnover.  |  Martinez, AL., et al. 2024. Mol Biol Cell. 35: ar64. PMID: 38507235

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NCAM/CD56 Antibody (123C3) has 61 citations in a variety of scientific publications.

Primary antibodies like Anti-NCAM/CD56 Antibody (123C3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NCAM/CD56 Antibody (123C3) Specifications

Alternate Product Name: CD56

Product Clone Name: 123C3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: NCAM

Epitope Species: human

Product Reactivity/Detection: NCAM

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 61 citations in various scientific publications

Available Conjugates/Forms for NCAM/CD56 Antibody (123C3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred NCAM/CD56 antibody is NCAM/CD56 Antibody (ERIC 1): sc-106.