NCAM/CD56 Antibody (123A8): sc-59864

NCAM Antibody (123A8) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to target the human Neural Cell Adhesion Molecule (NCAM), also known as CD56 or NCAM1. NCAM is a vital cell surface glycoprotein that facilitates cell-to-cell interactions essential for neural development, synaptic plasticity, and embryogenesis, playing a crucial role in the formation and maintenance of the nervous system. NCAM monoclonal antibody (123A8) effectively detects NCAM across multiple species, including mouse, rat, and human, and is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Beyond its applications in normal physiological studies, NCAM (123A8) monoclonal antibody is highly recommended for identifying and researching neuroectodermally derived tumors such as neuroblastoma, medulloblastoma, astrocytoma, and retinoblastoma, where NCAM expression is prominently observed. NCAM exists in multiple isoforms generated through alternative splicing and polyadenylation of a single gene located at chromosome 11q23 in humans, contributing to its diverse functional roles in both healthy and diseased states. Anti-NCAM antibody (123A8) aids researchers in elucidating the molecular mechanisms underlying cell adhesion, neural network formation, and the progression of various neuro-related cancers.

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NCAM/CD56 Antibody (123A8) References:

1. Extracellular protein interactions mediated by the neural cell adhesion molecule, NCAM: heterophilic interactions between NCAM and cell adhesion molecules, extracellular matrix proteins, and viruses.  |  Nielsen, J., et al. 2010. Adv Exp Med Biol. 663: 23-53. PMID: 20017013
2. The role of NCAM in auditory fear conditioning and its modulation by stress: a focus on the amygdala.  |  Bisaz, R. and Sandi, C. 2010. Genes Brain Behav. 9: 353-64. PMID: 20059553
3. NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation.  |  Puchkov, D., et al. 2011. Cereb Cortex. 21: 2217-32. PMID: 21339376
4. NCAM deficiency in the mouse forebrain impairs innate and learned avoidance behaviours.  |  Brandewiede, J., et al. 2014. Genes Brain Behav. 13: 468-77. PMID: 24751161
5. [The impact of polysialic acid (PSA) and polysialylated neural cell adhesion molecule (PSA-NCAM) on tumor and cell signaling pathways].  |  Wang, X. and Guan, F. 2014. Yi Chuan. 36: 739-46. PMID: 25143271
6. Perineuronal Net Protein Neurocan Inhibits NCAM/EphA3 Repellent Signaling in GABAergic Interneurons.  |  Sullivan, CS., et al. 2018. Sci Rep. 8: 6143. PMID: 29670169
7. Native-compound-Coupled Affinity Matrix (NCAM) in target identification and validation of bioactive compounds: Application, mechanism and outlooks.  |  Ma, L., et al. 2023. Bioorg Chem. 140: 106828. PMID: 37690368
8. Polysialylated NCAM expression on endocardial cells of the chick primary atrial septum.  |  Gerety, M. and Watanabe, M. 1997. Anat Rec. 247: 71-84. PMID: 8986305
9. NCAM is essential for axonal growth and fasciculation in the hippocampus.  |  Cremer, H., et al. 1997. Mol Cell Neurosci. 8: 323-35. PMID: 9073395
10. NCAM and schizophrenia: genetic studies.  |  Vicente, AM., et al. 1997. Mol Psychiatry. 2: 65-9. PMID: 9154219

The preferred NCAM/CD56 antibody is NCAM/CD56 Antibody (ERIC 1): sc-106.