NAT-1/2 Antibody (D-9): sc-398540

NAT-1/2 Antibody (D-9) is a mouse monoclonal IgG1 antibody that detects Arylamine N-acetyltransferase-1 and -2 (NAT-1 and NAT-2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-NAT-1/2 antibody (D-9) plays a crucial role in understanding the function of NAT-1 and NAT-2, which are essential enzymes involved in the N- or O-acetylation of various heterocyclic and arylamine substrates, thereby facilitating the detoxification of numerous drugs. NAT-1/2 (D-9) antibody helps researchers study these proteins′ ability to bioactivate certain carcinogens, with specific alleles linked to increased N-acetyltransferase activity associated with a higher risk of developing colon and urinary bladder cancers. Both NAT-1 and NAT-2 are located in the cytoplasm, where they actively participate in the detoxification processes, and their polymorphic nature in liver tissues can significantly influence the metabolism and toxicity of amine-containing drugs. Understanding the interactions and functions of NAT-1 and NAT-2 is vital for developing targeted therapies and improving drug safety profiles, making NAT-1/2 (D-9) monoclonal antibody an invaluable tool for researchers in the field of pharmacogenomics and cancer research.

The preferred NAT-1/2 antibody is NAT-1/2 Antibody (G-5): sc-137204.