nardilysin Antibody (G-9): sc-166876

nardilysin Antibody (G-9) is a mouse monoclonal IgG2b antibody that detects nardilysin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nardilysin is a 1,147 amino acid metalloendopeptidase that plays a crucial role in the activation of protein precursors by cleaving at the amino-terminus of arginine residues in dibasic moieties, which is essential for various physiological processes, including cell signaling and migration. Nardilysin is primarily expressed in adult heart, skeletal muscle, and testis, with expression in the testis being restricted to germ cells, highlighting nardilysin′s importance in reproductive biology. As a member of the insulinase family, nardilysin serves as a specific receptor for heparin-binding epidermal growth factor-like growth factor (HB-EGF), modulating HB-EGF-induced cell migration via the ErbB1 pathway, which is vital for tissue development and repair. Additionally, nardilysin exhibits significant similarity to insulinase and yeast processing enzymes, indicating evolutionary conservation and functional significance. Defects in the gene encoding nardilysin have been linked to inherited neuromuscular disorders, underscoring nardilysin′s relevance in both health and disease. anti-nardilysin antibody (G-9) is an invaluable tool for researchers studying the intricate roles of this protease in various biological contexts.

The preferred nardilysin antibody is nardilysin Antibody (A-6): sc-137199.