nardilysin Antibody (A-6): sc-137199
- nardilysin Antibody (A-6) is a mouse monoclonal IgG1 κ nardilysin antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 64-83 near the N-terminus of nardilysin of human origin
- nardilysin Antibody (A-6) is recommended for detection of nardilysin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-nardilysin Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for nardilysin Antibody (A-6) for WB applications. These reagents are now offered in bundles with nardilysin Antibody (A-6) (see ordering information below).
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nardilysin Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects nardilysin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-nardilysin antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Nardilysin, also known as N-arginine dibasic convertase, NRD1, or NRD convertase, is a 1,147 amino acid metalloendopeptidase that plays a crucial role in processing propeptide and proprotein substrates by cleaving at the amino-terminus of arginine residues in dibasic motifs. This enzymatic activity is vital for the activation of various protein precursors, which can influence numerous physiological processes, including cell signaling and migration. The nardilysin gene is located on chromosome 1p32.2 and is primarily expressed as a 3.6-kb transcript in adult heart, skeletal muscle, and testis, with expression in the testis being restricted to germ cells. As a member of the insulinase family, nardilysin serves as a specific receptor for heparin-binding epidermal growth factor-like growth factor (HB-EGF), modulating HB-EGF-induced cell migration through the ErbB1 pathway. Notably, nardilysin exhibits significant similarity to insulinase and two yeast processing enzymes, Axl1 and Ste2, highlighting its evolutionary conservation and functional importance. Defects in the gene encoding nardilysin have been associated with inherited neuromuscular disorders, underscoring its critical role in human health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
nardilysin Antibody (A-6) References:
- N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. | Nishi, E., et al. 2001. EMBO J. 20: 3342-50. PMID: 11432822
- N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes. | Pierotti, AR., et al. 1994. Proc Natl Acad Sci U S A. 91: 6078-82. PMID: 8016118
- NRD convertase: a putative processing endoprotease associated with the axoneme and the manchette in late spermatids. | Chesneau, V., et al. 1996. J Cell Sci. 109 (Pt 11): 2737-45. PMID: 8937991
- Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. | Fumagalli, P., et al. 1998. Genomics. 47: 238-45. PMID: 9479496
- Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. | Hospital, V., et al. 1997. Biochem J. 327 (Pt 3): 773-9. PMID: 9581555
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
nardilysin Antibody (A-6) | sc-137199 | 200 µg/ml | $316.00 | |||
nardilysin Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-528873 | 200 µg Ab; 10 µg BP | $354.00 | |||
nardilysin Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-521448 | 200 µg Ab, 40 µg BP | $354.00 | |||
nardilysin Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-543183 | 200 µg Ab; 20 µg BP | $354.00 | |||
nardilysin Antibody (A-6) AC | sc-137199 AC | 500 µg/ml, 25% agarose | $416.00 | |||
nardilysin Antibody (A-6) HRP | sc-137199 HRP | 200 µg/ml | $316.00 | |||
nardilysin Antibody (A-6) FITC | sc-137199 FITC | 200 µg/ml | $330.00 | |||
nardilysin Antibody (A-6) PE | sc-137199 PE | 200 µg/ml | $343.00 | |||
nardilysin Antibody (A-6) Alexa Fluor® 488 | sc-137199 AF488 | 200 µg/ml | $357.00 | |||
nardilysin Antibody (A-6) Alexa Fluor® 546 | sc-137199 AF546 | 200 µg/ml | $357.00 | |||
nardilysin Antibody (A-6) Alexa Fluor® 594 | sc-137199 AF594 | 200 µg/ml | $357.00 | |||
nardilysin Antibody (A-6) Alexa Fluor® 647 | sc-137199 AF647 | 200 µg/ml | $357.00 | |||
nardilysin Antibody (A-6) Alexa Fluor® 680 | sc-137199 AF680 | 200 µg/ml | $357.00 | |||
nardilysin Antibody (A-6) Alexa Fluor® 790 | sc-137199 AF790 | 200 µg/ml | $357.00 | |||
nardilysin (A-6) Neutralizing Peptide | sc-137199 P | 100 µg/0.5 ml | $68.00 |