NANS Antibody (B-1): sc-514091
- NANS Antibody (B-1) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 84-102 within an internal region of NANS of human origin
- recommended for detection of NANS of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NANS Antibody (B-1). This work is in progress.
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SEE ALSO...
NANS Antibody (B-1) is a mouse monoclonal IgM antibody that detects N-acetylneuraminic acid synthase (NANS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NANS is a crucial enzyme in the biosynthesis of sialic acids, which are essential for various cellular recognition processes, including cell signaling and pathogen interactions. NANS (B-1) antibody recognizes a protein consisting of 359 amino acids with an antifreeze protein-like domain, highlighting its evolutionary significance. NANS catalyzes the formation of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) from specific substrates, namely N-acetylmannosamine 6-phosphate and mannose 6-phosphate, respectively. This enzymatic activity is vital for maintaining cellular functions and modulating immune responses. Notably, human NANS shares 36% sequence identity with the E. coli neuB protein, indicating a conserved role in sialic acid metabolism across species. Anti-NANS antibody (B-1) serves as an invaluable tool for researchers studying the dynamics of sialic acid biosynthesis and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NANS Antibody (B-1) | sc-514091 | 200 µg/ml | $316.00 | |||
NANS (B-1) Neutralizing Peptide | sc-514091 P | 100 µg/0.5 ml | $68.00 |