NAB2 Antibody (1C4): sc-23867

NAB2 Antibody (1C4) is a mouse monoclonal IgG1 kappa light chain antibody that detects NAB2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. NAB2 (1C4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NAB2 protein plays a crucial role in transcriptional regulation, primarily functioning as a corepressor of transcription factor Egr-1/NGFI-A. This interaction maintains gene expression balance, as NAB2 helps modulate NGFI-A activity, which is involved in essential cellular processes such as cell division, differentiation, and apoptosis. NAB2 is predominantly localized in the nucleus, where NAB2 exerts regulatory functions, and is encoded by a gene located on chromosome 12q13.3-14.1, a region frequently altered in various solid tumors, lipomas, and liposarcomas. NAB2′s presence in these regions underscores its potential significance in cancer biology, making anti-NAB2 antibody (1C4) an invaluable tool for researchers investigating molecular mechanisms underlying tumorigenesis and cellular regulation.

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NAB2 Antibody (1C4) References:

1. A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene.  |  Sevetson, BR., et al. 2000. J Biol Chem. 275: 9749-57. PMID: 10734128
2. Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature.  |  Yuzawa, S., et al. 2016. Am J Surg Pathol. 40: 1031-40. PMID: 26927892
3. Nab2 maintains thymus cellularity with aging and stress.  |  Hastings, KT., et al. 2017. Mol Immunol. 85: 185-195. PMID: 28282643
4. Structure-function relationships in the Nab2 polyadenosine-RNA binding Zn finger protein family.  |  Fasken, MB., et al. 2019. Protein Sci. 28: 513-523. PMID: 30578643
5. The disease-associated proteins Drosophila Nab2 and Ataxin-2 interact with shared RNAs and coregulate neuronal morphology.  |  Rounds, JC., et al. 2022. Genetics. 220: PMID: 34791182
6. The Nab2 RNA-binding protein patterns dendritic and axonal projections through a planar cell polarity-sensitive mechanism.  |  Corgiat, EB., et al. 2022. G3 (Bethesda). 12: PMID: 35471546
7. NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors.  |  Eschbacher, KL., et al. 2024. Brain Pathol. 34: e13256. PMID: 38523251
8. NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors.  |  Hill, CM., et al. 2024. bioRxiv.. PMID: 38659891
9. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.  |  Russo, MW., et al. 1995. Proc Natl Acad Sci U S A. 92: 6873-7. PMID: 7624335
10. Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor.  |  Russo, MW., et al. 1993. Mol Cell Biol. 13: 6858-65. PMID: 8413279
11. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.  |  Svaren, J., et al. 1996. Mol Cell Biol. 16: 3545-53. PMID: 8668170
12. Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain.  |  Swirnoff, AH., et al. 1998. Mol Cell Biol. 18: 512-24. PMID: 9418898

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NAB2 Antibody (1C4) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-NAB2 Antibody (1C4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NAB2 Antibody (1C4) Specifications

Alternate Product Name: NAB2

Product Clone Name: 1C4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: NAB2

Epitope Species: human

Product Reactivity/Detection: NAB2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for NAB2 Antibody (1C4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin