Date published: 2025-12-17

1-800-457-3801

SCBT Portrait Logo
Seach Input

NAB2 Inhibitors

NAB2 inhibitors constitute a diverse array of chemicals that primarily target epigenetic regulators, focusing on histone methylation patterns to modulate gene expression associated with NAB2-related pathways. Small molecule inhibitors such as BIX-01294 and UNC1999 selectively target G9a, an important histone methyltransferase, impacting the epigenetic landscape by altering histone methylation patterns. Concurrently, compounds like 3-Deazaneplanocin A (DZNep) and GSK-J4 target EZH2, a component of the polycomb repressive complex 2 (PRC2), contributing to epigenetic modifications. Histone demethylase inhibitors, including GSK343 and JQ1, exert their effects on JMJD3 and BET proteins, respectively, influencing chromatin remodeling and transcriptional regulation. Additionally, EPZ-6438, CPI-360, and UNC2400 selectively inhibit EZH2, thereby modulating histone methylation patterns and impacting the epigenetic regulation of genes associated with NAB2. Chaetocin, a natural product, targets the histone methyltransferase SUV39H1, contributing to the modulation of histone methylation patterns and the epigenetic regulation of NAB2-related pathways. The collective action of these inhibitors highlights the intricate relationship between epigenetic modifications and the expression of genes involved in cellular processes associated with NAB2. Researchers exploring these compounds gain valuable insights into strategies for manipulating the epigenetic regulation of NAB2, offering a foundation for further investigation into the complex interplay of chromatin dynamics in cellular physiology.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Histone Lysine Methyltransferase Inhibitor Inhibitor

935693-62-2 (free base)sc-202651
5 mg
$148.00
4
(1)

BIX-01294 is a small molecule inhibitor of G9a and GLP, affecting histone methylation. By inhibiting G9a, BIX-01294 indirectly modulates the epigenetic landscape, potentially impacting the expression of genes involved in pathways related to NAB2.

GSK-J4

1373423-53-0sc-507551
100 mg
$1275.00
(0)

GSK-J4 is a selective inhibitor of the histone demethylase JMJD3. By inhibiting JMJD3, GSK-J4 modulates histone methylation patterns, potentially impacting the epigenetic regulation of genes involved in pathways associated with NAB2.

EPZ6438

1403254-99-8sc-507456
1 mg
$66.00
(0)

EPZ-6438 is a selective inhibitor of the histone methyltransferase EZH2. By inhibiting EZH2, EPZ-6438 modulates histone methylation, influencing the epigenetic regulation of genes associated with NAB2-related pathways.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$226.00
$846.00
1
(0)

JQ1 is a small molecule inhibitor that targets bromodomain-containing proteins, including BET proteins. By inhibiting BET proteins, JQ1 affects chromatin remodeling and transcriptional regulation, potentially impacting the expression of genes involved in pathways related to NAB2.

GSK126

1346574-57-9sc-490133
sc-490133A
sc-490133B
1 mg
5 mg
10 mg
$90.00
$238.00
$300.00
(0)

GSK126 is a selective inhibitor of the histone methyltransferase EZH2. By inhibiting EZH2, GSK126 modulates histone methylation patterns, potentially impacting the epigenetic regulation of genes involved in pathways associated with NAB2.

UNC1999

1431612-23-5sc-475314
5 mg
$142.00
1
(0)

UNC1999 is a selective inhibitor of the histone methyltransferase G9a. By inhibiting G9a, UNC1999 modulates histone methylation, potentially impacting the epigenetic regulation of genes involved in pathways associated with NAB2.

CPI-360

1802175-06-9sc-507464
1 mg
$100.00
(0)

CPI-360 is a small molecule inhibitor of the histone methyltransferase EZH2. By inhibiting EZH2, CPI-360 modulates histone methylation patterns, potentially impacting the epigenetic regulation of genes involved in pathways associated with NAB2.

Chaetocin

28097-03-2sc-200893
200 µg
$120.00
5
(1)

Chaetocin is a natural product inhibitor of the histone methyltransferase SUV39H1. By inhibiting SUV39H1, Chaetocin modulates histone methylation patterns, potentially impacting the epigenetic regulation of genes involved in pathways associated with NAB2.

I-BET 151 Hydrochloride

1300031-49-5 (non HCl Salt)sc-391115
10 mg
$450.00
2
(0)

I-BET151 is a small molecule inhibitor targeting BET bromodomains. By inhibiting BET proteins, I-BET151 affects chromatin remodeling and transcriptional regulation, potentially impacting the expression of genes involved in pathways related to NAB2.