NAB2 Activators
The chemical class of NAB2 activators encompasses a diverse range of compounds that can modulate the activity of NAB2, a transcriptional repressor involved in the regulation of various cellular processes. These compounds, while not directly binding to NAB2, exert their influence through intricate cellular pathways, ultimately leading to enhanced NAB2 expression and function. One group of NAB2 activators includes AMPK activators, exemplified by A769662 and Berberine. These compounds indirectly activate NAB2 by modulating cellular energy status through AMPK activation. The changes in cellular energy status impact downstream signaling pathways, enhancing NAB2 expression and function in cellular processes. Calcium ionophores, such as A23187, directly activate NAB2 by facilitating calcium influx into the cytoplasm. The activation of calcium-dependent signaling pathways leads to changes in the cellular environment, ultimately enhancing NAB2 expression and function in cellular processes.
Inhibitors of specific kinases, like GW5074 targeting Raf-1 kinase, LY294002 inhibiting PI3K, and Selumetinib inhibiting MEK1/2, indirectly activate NAB2 by altering signaling pathways crucial for NAB2 regulation. These compounds impact the cellular environment, leading to enhanced NAB2 expression and function. Modulators of GPR55, exemplified by O-1602, indirectly activate NAB2 by binding to GPR55 and modulating downstream signaling pathways. The influence on the cellular environment leads to enhanced NAB2 expression and function in cellular processes. Furthermore, compounds like SB216763, an inhibitor of GSK-3β, and Tautomycin, an inhibitor of protein phosphatases PP1 and PP2A, indirectly activate NAB2 by disrupting negative regulation and influencing the cellular environment. These compounds promote enhanced NAB2 expression and function. In summary, the NAB2 activators represent a collection of compounds that modulate NAB2 activity through diverse signaling pathways.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator that indirectly influences NAB2. By activating AMPK, A769662 modulates cellular energy status and downstream signaling pathways. The activation of AMPK leads to changes in the cellular environment, impacting NAB2 expression and function in cellular processes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that directly activates NAB2. It facilitates the influx of calcium ions into the cytoplasm, leading to the activation of calcium-dependent signaling pathways. NAB2 activation occurs through the modulation of calcium-responsive proteins and downstream signaling events, ultimately enhancing NAB2 expression and function in cellular processes. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a potent activator of stress-activated protein kinases (SAPKs), including p38 MAPK. It indirectly activates NAB2 by modulating the p38 MAPK signaling pathway. The activation of p38 MAPK leads to changes in the cellular environment, impacting NAB2 expression and function in cellular processes. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is an alkaloid that indirectly activates NAB2 by influencing AMPK signaling. By activating AMPK, berberine modulates cellular energy status and downstream signaling pathways. The activation of AMPK leads to changes in the cellular environment, impacting NAB2 expression and function in cellular processes. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a selective inhibitor of Raf-1 kinase and indirectly activates NAB2. By inhibiting Raf-1 kinase, GW5074 disrupts the negative regulation exerted by Raf-1 on NAB2. This compound influences the cellular environment, leading to the activation of NAB2 through the relief of inhibitory signals emanating from the Raf-1 kinase pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K) and indirectly activates NAB2. By inhibiting PI3K, LY294002 disrupts signaling pathways involved in NAB2 regulation. The inhibition of PI3K alters the cellular environment, leading to the activation of NAB2 through the modulation of key proteins and downstream signaling events. | ||||||
O-1602 | 317321-41-8 | sc-202745 sc-202745A | 1 mg 5 mg | $208.00 $416.00 | ||
O-1602 is a synthetic agonist of G protein-coupled receptor GPR55 and indirectly activates NAB2. By binding to GPR55, O-1602 modulates downstream signaling pathways, influencing the cellular environment and NAB2 expression and function in cellular processes. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Prostratin is a protein kinase C (PKC) activator that indirectly activates NAB2. By activating PKC, prostratin modulates downstream signaling pathways, leading to changes in the cellular environment that impact NAB2 expression and function in cellular processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound that indirectly activates NAB2 by influencing SIRT1 and AMPK signaling pathways. The activation of SIRT1 and AMPK by resveratrol leads to changes in the cellular environment, impacting NAB2 expression and function in cellular processes. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 is a selective inhibitor of glycogen synthase kinase-3β (GSK-3β) and indirectly activates NAB2. By inhibiting GSK-3β, SB216763 modulates Wnt signaling, which is intricately linked to NAB2 regulation. This compound indirectly activates NAB2 by altering the cellular environment necessary for efficient NAB2 expression and function in cellular processes. | ||||||