N-Myc Antibody (2): sc-142
- N-Myc Antibody (2) is a mouse monoclonal IgG2a, cited in 15 publications, provided at 200 µg/ml
- epitope mapping at residues 327-339 of N-Myc of human origin
- Anti-N-Myc Antibody (2) is recommended for detection of N-Myc p67 of mouse, rat and human origin by WB, IP and IF
- Anti-N-Myc Antibody (2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for N-Myc Antibody (2). This work is in progress.
QUICK LINKS
N-Myc Antibody (2) is a mouse monoclonal IgG2a antibody that detects N-Myc p67 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. Anti-N-Myc antibody (2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. N-Myc, a member of the Myc family of oncogenes, plays a crucial role in cell proliferation, differentiation, and apoptosis, making N-Myc a significant factor in cancer biology. N-Myc amplification is particularly relevant in neuroblastomas, where N-Myc has been shown to correlate with disease progression, highlighting N-Myc′s potential as a biomarker for diagnosis and prognosis. Structurally, N-Myc is a nuclear phosphoprotein that undergoes rapid degradation, with a half-life of approximately 30 minutes in vivo, which is essential for regulating N-Myc activity and preventing uncontrolled cell growth. N-Myc′s ability to bind DNA in a sequence-specific manner, following dimerization with the Max protein, underscores N-Myc′s importance in transcriptional regulation and oncogenic processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
N-Myc Antibody (2) References:
- N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. | Dardenne, E., et al. 2016. Cancer Cell. 30: 563-577. PMID: 27728805
- N-myc Downstream-Regulated Gene 1 and Endometriosis: A Minireview. | Lou, T., et al. 2017. Crit Rev Eukaryot Gene Expr. 27: 341-345. PMID: 29283328
- N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer. | Berger, A., et al. 2019. J Clin Invest. 129: 3924-3940. PMID: 31260412
- N-Myc a key gene promoting a worst prostate cancer progression. | Di Nunno, V., et al. 2019. Transl Cancer Res. 8: E15-E17. PMID: 35117057
- N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma. | Kuzuoglu-Ozturk, D., et al. 2023. Cancer Res. 83: 130-140. PMID: 36264168
- Targeting protein folding in N-Myc-driven medulloblastoma. | Valinciute, G. and Roussel, MF. 2023. Mol Oncol. 17: 387-389. PMID: 36786675
- N-MYC-interacting protein enhances type II interferon signaling by inhibiting STAT1 sumoylation. | Feng, L., et al. 2023. FASEB J. 37: e23281. PMID: 37933920
- N-MYC regulates cell survival via eIF4G1 in inv(16) acute myeloid leukemia. | Peramangalam, PS., et al. 2024. Sci Adv. 10: eadh8493. PMID: 38416825
- N-MYC impairs innate immune signaling in high-grade serous ovarian carcinoma. | Miranda, A., et al. 2024. Sci Adv. 10: eadj5428. PMID: 38748789
- Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer. | Xu, P., et al. 2024. Nat Commun. 15: 6626. PMID: 39103353
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Myc Antibody (2) | sc-142 | 200 µg/ml | $322.00 | |||
N-Myc Antibody (2) AC | sc-142 AC | 500 µg/ml, 25% agarose | $424.00 | |||
N-Myc Antibody (2) HRP | sc-142 HRP | 200 µg/ml | $322.00 | |||
N-Myc Antibody (2) FITC | sc-142 FITC | 200 µg/ml | $336.00 | |||
N-Myc Antibody (2) PE | sc-142 PE | 200 µg/ml | $349.00 | |||
N-Myc Antibody (2) Alexa Fluor® 488 | sc-142 AF488 | 200 µg/ml | $364.00 | |||
N-Myc Antibody (2) Alexa Fluor® 546 | sc-142 AF546 | 200 µg/ml | $364.00 | |||
N-Myc Antibody (2) Alexa Fluor® 594 | sc-142 AF594 | 200 µg/ml | $364.00 | |||
N-Myc Antibody (2) Alexa Fluor® 647 | sc-142 AF647 | 200 µg/ml | $364.00 | |||
N-Myc Antibody (2) Alexa Fluor® 680 | sc-142 AF680 | 200 µg/ml | $364.00 | |||
N-Myc Antibody (2) Alexa Fluor® 790 | sc-142 AF790 | 200 µg/ml | $364.00 |