N-Myc Activators
N-Myc activators represent a class of chemical compounds that are involved in the modulation of N-Myc, a member of the Myc family of transcription factors. N-Myc is a pivotal regulator of gene expression, playing a critical role in the control of various cellular processes, including cell growth, proliferation, and differentiation. These activators are characterized by their ability to enhance the transcriptional activity of N-Myc by facilitating its binding to specific target genes and regulatory elements.
The activation of N-Myc is crucial for the orchestration of intricate genetic programs that govern various aspects of normal cellular development and function. N-Myc activators exert their influence through diverse mechanisms, often involving the stabilization of N-Myc protein or the enhancement of its DNA-binding affinity. This, in turn, leads to increased N-Myc-mediated gene transcription, ultimately affecting the expression of genes involved in essential cellular processes such as cell cycle progression, metabolism, and differentiation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
These are known activators of protein kinase C (PKC). Activation of PKC can modulate various transcription factors, including potentially Myc family proteins, either by direct phosphorylation or through downstream signaling cascades. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
This compound inhibits protein synthesis. While its primary action isn't on N-Myc directly, it can indirectly influence N-Myc levels by preventing the degradation of the protein, thus allowing researchers to study its half-life and turnover. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Known to inhibit GSK3β, a kinase involved in the degradation pathway of Myc proteins. By inhibiting GSK3β, lithium chloride might stabilize N-Myc, leading to its increased activity. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
Also an inhibitor of GSK3β, BIO can potentially stabilize Myc proteins by preventing their degradation, thus enhancing N-Myc activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 can activate various signaling pathways, which might have downstream effects leading to the modulation or activation of transcription factors like N-Myc. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
This compound activates adenylate cyclase, leading to increased levels of cAMP in the cell. Elevated cAMP can stimulate various signaling pathways that might indirectly modulate N-Myc activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
As a β-adrenergic agonist, isoproterenol can activate downstream signaling pathways associated with β-adrenergic receptors, which might indirectly influence N-Myc levels or activity. | ||||||
L-phenylephrine | 59-42-7 | sc-295315 sc-295315A | 5 g 25 g | $181.00 $492.00 | 2 | |
An α-adrenergic agonist, phenylephrine activates signaling pathways associated with α-adrenergic receptors. This can potentially have downstream effects on various transcription factors, including N-Myc. | ||||||