Myosin XVIIIB Antibody (D-11): sc-515011

Myosin XVIIIB Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Myosin XVIIIB protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Myosin XVIIIB antibody (D-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Myosin XVIIIB, also known as MYO18B, is a 2,567 amino acid unconventional myosin heavy chain predominantly expressed in human cardiac and skeletal muscles, with lower expression levels in testis. Myosin XVIIIB plays a significant role in cellular motility and muscle contraction by transporting cellular components along actin filaments. Myosin XVIIIB is localized in cytoplasm of undifferentiated myoblast cells, featuring an N-terminal head domain that acts as a motor with ATP-binding site and actin-binding region, a neck region containing IQ motif, and C-terminal tail with short coiled-coil domain facilitating dimerization to form two-headed structure. Sug1, a regulator of 26S proteasome, interacts with C-terminal tail of Myosin XVIIIB, leading to upregulation. Dysregulation of Myosin XVIIIB is implicated in lung and ovarian cancers, where Myosin XVIIIB is often deleted, mutated, or hypermethylated, suggesting a role as tumor suppressor. Expression of Myosin XVIIIB is influenced by histone modifications, particularly deacetylation of histones H3 and H4 surrounding promoter region, potentially contributing to cancer pathogenesis.

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Myosin XVIIIB Antibody (D-11) References:

1. MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.  |  Nishioka, M., et al. 2002. Proc Natl Acad Sci U S A. 99: 12269-74. PMID: 12209013
2. Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.  |  Salamon, M., et al. 2003. J Mol Biol. 326: 137-49. PMID: 12547197
3. Genetic alterations responsible for metastatic phenotypes of lung cancer cells.  |  Yokota, J., et al. 2003. Clin Exp Metastasis. 20: 189-93. PMID: 12741677
4. Molecular footprints of human lung cancer progression.  |  Yokota, J. and Kohno, T. 2004. Cancer Sci. 95: 197-204. PMID: 15016317
5. Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells.  |  Tani, M., et al. 2004. Genes Chromosomes Cancer. 40: 146-51. PMID: 15101048
6. Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer.  |  Yanaihara, N., et al. 2004. Int J Cancer. 112: 150-4. PMID: 15305387
7. Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer.  |  Nakano, T., et al. 2005. Genes Chromosomes Cancer. 43: 162-71. PMID: 15751041

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Myosin XVIIIB Antibody (D-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Myosin XVIIIB Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Myosin XVIIIB Antibody (D-11) Specifications

Alternate Product Name: Myosin XVIIIB

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1801-1930

Epitope Target: Myosin XVIIIB

Epitope Species: human

Product Reactivity/Detection: Myosin XVIIIB isoforms 1 and 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Myosin XVIIIB Antibody (D-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin