Myosin XVIIIb Activators
Myosin XVIIIb activators encompass a variety of compounds that influence the actin cytoskeleton and myosin phosphorylation states. Phalloidin and jasplakinolide directly enhance the functional activity of Myosin XVIIIb by stabilizing actin filaments, thus providing a robust substrate for myosin's ATPase activity. Calyculin A indirectly augments Myosin XVIIIb activity by inhibiting phosphatases that would normally decrease the phosphorylation state of myosin light chains, while ML-7 modulates the phosphorylation indirectly through the inhibition of MLCK, amplifying Myosin XVIIIb's function when other kinase pathways are available.
Further influencing Myosin XVIIIb's activity, the modulation of competitive myosin ATPases by compounds like blebbistatin and its enantiomer can reallocate the cellular actin-myosin interaction balance in favor of Myosin XVIIIb. Y-27632's inhibition of ROCK alters myosin light chain phosphorylation dynamics, which can indirectly heighten Myosin XVIIIb's motor function. Similarly, altering actinMyosin XVIIIb activators are chemicals that influence the actin cytoskeleton and myosin phosphorylation states, ultimately enhancing the functional activity of Myosin XVIIIb. Phalloidin and jasplakinolide contribute to this activation by stabilizing actin filaments, thus providing a robust substrate for Myosin XVIIIb's ATPase activity. The stabilization of actin filaments by these compounds ensures that Myosin XVIIIb has an optimal pathway for its movement and force generation. Calyculin A also plays a role in this process; by inhibiting phosphatases that dephosphorylate myosin light chains, Calyculin A maintains a high phosphorylation state of myosin light chains, indirectly enhancing Myosin XVIIIb's motor function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin stabilizes actin filaments and enhances actin polymerization. Myosin XVIIIb, functioning as an actin-based motor protein, is activated as the stable actin filaments provide a more robust track for myosin's ATPase activity. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide promotes actin filament stabilization and nucleation, leading to enhanced actin dynamics. This stabilization indirectly enhances Myosin XVIIIb activity by optimizing the actin network it interacts with. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a phosphatase inhibitor that prevents dephosphorylation of myosin light chains, thus enhancing myosin activity. By maintaining phosphorylation, Myosin XVIIIb's motor function is indirectly enhanced. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is an inhibitor of formin-mediated actin assembly. By modulating actin dynamics, Myosin XVIIIb activity can be indirectly enhanced through alterations in the actin architecture it interacts with. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 inhibits the Arp2/3 complex, which modulates actin branching. By limiting actin branching, Myosin XVIIIb may engage with actin filaments more effectively, enhancing its motor activity. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 is another inhibitor of the Arp2/3 complex, functioning similarly to CK-666. It may indirectly enhance Myosin XVIIIb activity by simplifying the actin network. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin B binds to actin monomers and prevents their polymerization. By transiently disrupting the actin cytoskeleton, it can lead to compensatory mechanisms that enhance Myosin XVIIIb's interaction with actin upon reassembly. | ||||||