Myo-inositol oxygenase Antibody (D-11): sc-271512

Myo-inositol oxygenase Antibody (D-11) is a mouse monoclonal IgG2a antibody that detects Myo-inositol oxygenase in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Myo-inositol oxygenase, also known as ALDRL6, plays a crucial role in the metabolism of Myo-inositol, catalyzing the first committed step in this pathway, which is essential for cellular signaling and osmoregulation. Myo-inositol oxygenase is predominantly found in the kidneys, highlighting its importance in renal function and the regulation of osmotic balance. Myo-inositol oxygenase activity is particularly significant in diabetic nephropathy, where dysregulation of Myo-inositol metabolism can contribute to the progression of kidney complications associated with diabetes. Myo-inositol oxygenase monoclonql antibody (D-11) exhibits a high degree of sequence homology with homologs in other species, sharing 91% and 96% identity with mouse and pig counterparts, respectively, which underscores evolutionary conservation and potential as a therapeutic target Myo-inositol oxygenase′s unique structure, featuring a binuclear iron center, is critical for dioxygen-dependent catalytic activity, enabling the oxidative cleavage of Myo-inositol and its epimer, D-chiro inositol, to produce D-glucuronate. This intricate mechanism not only highlights Myo-inositol oxygenase′s biochemical significance but also potential implications in metabolic disorders, making anti-Myo-inositol oxygenase antibody (D-11) an invaluable tool for researchers studying renal physiology and related pathologies.

The preferred Myo-inositol oxygenase antibody is Myo-inositol oxygenase Antibody (E-11): sc-376080.