Myo-inositol oxygenase Antibody (D-11): sc-271512
- Myo-inositol oxygenase Antibody (D-11) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 1-285 representing full length Myo-inositol oxygenase of human origin
- recommended for detection of Myo-inositol oxygenase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Myo-inositol oxygenase Antibody (D-11) for WB and IHC(P) applications. These reagents are now offered in bundles with Myo-inositol oxygenase Antibody (D-11) (see ordering information below).
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Myo-inositol oxygenase Antibody (D-11) is a mouse monoclonal IgG2a antibody that detects Myo-inositol oxygenase in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Myo-inositol oxygenase, also known as ALDRL6, plays a crucial role in the metabolism of Myo-inositol, catalyzing the first committed step in this pathway, which is essential for cellular signaling and osmoregulation. Myo-inositol oxygenase is predominantly found in the kidneys, highlighting its importance in renal function and the regulation of osmotic balance. Myo-inositol oxygenase activity is particularly significant in diabetic nephropathy, where dysregulation of Myo-inositol metabolism can contribute to the progression of kidney complications associated with diabetes. Myo-inositol oxygenase monoclonql antibody (D-11) exhibits a high degree of sequence homology with homologs in other species, sharing 91% and 96% identity with mouse and pig counterparts, respectively, which underscores evolutionary conservation and potential as a therapeutic target Myo-inositol oxygenase′s unique structure, featuring a binuclear iron center, is critical for dioxygen-dependent catalytic activity, enabling the oxidative cleavage of Myo-inositol and its epimer, D-chiro inositol, to produce D-glucuronate. This intricate mechanism not only highlights Myo-inositol oxygenase′s biochemical significance but also potential implications in metabolic disorders, making anti-Myo-inositol oxygenase antibody (D-11) an invaluable tool for researchers studying renal physiology and related pathologies.
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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.
Download thiomersal SDS
Myo-inositol oxygenase Antibody (D-11) References:
- Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells. | Prabhu, KS., et al. 2005. J Biol Chem. 280: 19895-901. PMID: 15778219
- myo-Inositol oxygenase: a novel kidney-specific biomarker of acute kidney injury? | Konvalinka, A. 2014. Clin Chem. 60: 708-10. PMID: 24607482
- Does myo-inositol oxygenase, the only enzyme to catalyze myo-inositol in vivo, play a role in the etiology of polycystic ovarian syndrome? | Mertoglu, C., et al. 2018. Gynecol Endocrinol. 34: 418-421. PMID: 29187000
- Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress. | Tominaga, T., et al. 2019. Am J Physiol Renal Physiol. 316: F301-F315. PMID: 30539651
- Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule. | Deng, F., et al. 2019. J Clin Invest. 129: 5033-5049. PMID: 31437128
- Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes. | Sharma, I., et al. 2020. Diabetes. 69: 1248-1263. PMID: 32169892
- Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans. | Wang, Y., et al. 2021. mBio. 12: e0279021. PMID: 34724824
- Myo-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis. | Zheng, X., et al. 2022. Am J Physiol Renal Physiol. 322: F344-F359. PMID: 35100813
- Myo-inositol oxygenase in cadmium-induced kidney injury. | Lu, Y. and Agarwal, A. 2022. Am J Physiol Renal Physiol. 322: F470-F472. PMID: 35285275
- Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome. | Zhou, W., et al. 2023. Immun Inflamm Dis. 11: e829. PMID: 37249295
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myo-inositol oxygenase Antibody (D-11) | sc-271512 | 200 µg/ml | $322.00 | |||
Myo-inositol oxygenase Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-537649 | 200 µg Ab; 10 µg BP | $361.00 | |||
Myo-inositol oxygenase Antibody (D-11): m-IgGκ BP-HRP Bundle | sc-534983 | 200 µg Ab; 40 µg BP | $361.00 | |||
Myo-inositol oxygenase Antibody (D-11): m-IgG2a BP-HRP Bundle | sc-548076 | 200 µg Ab; 10 µg BP | $361.00 |