Myosin-2/MYH2 Antibody (N2.261): sc-53096

MYH2 Antibody (N2.261) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect the myosin heavy chain protein encoded by the MYH2 gene, also known as Myosin Heavy Chain IIa (MyHC-IIa), in mouse, rat, human, rabbit, and fish tissues. MYH2 plays a crucial role in skeletal muscle contraction by interacting with actin to generate the force necessary for muscle movement, making it essential for locomotion and overall muscle function. MYH2 is predominantly found in type IIa fast-twitch muscle fibers, which are responsible for rapid and powerful contractions, thereby contributing significantly to muscle performance and endurance. MYH2 undergoes various post-translational modifications that regulate its motor activity and interactions with other muscle proteins, ensuring precise control of muscle contraction and relaxation cycles. By targeting neonatal slow-like MYH2, MYH2 (N2.261) antibody facilitates detailed studies of muscle development, fiber type specification, and the molecular mechanisms underlying muscle-related diseases. MYH2 monoclonal antibody (N2.261) is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP), providing versatile applications for comprehensive muscle biology research. Anti-MYH2 antibody (N2.261) serves as an invaluable tool for scientists investigating the functional dynamics of myosin in various muscle types and species.

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Myosin-2/MYH2 Antibody (N2.261) References:

1. Flexibility within the heads of muscle myosin-2 molecules.  |  Billington, N., et al. 2014. J Mol Biol. 426: 894-907. PMID: 24333017
2. Characterization of Blebbistatin Inhibition of Smooth Muscle Myosin and Nonmuscle Myosin-2.  |  Zhang, HM., et al. 2017. Biochemistry. 56: 4235-4243. PMID: 28714309
3. Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties.  |  Melli, L., et al. 2018. Elife. 7: PMID: 29419377
4. MYH2 myopathy, a new case expands the clinical and pathological spectrum of the recessive form.  |  Telese, R., et al. 2020. Mol Genet Genomic Med. 8: e1320. PMID: 32578970
5. Novel mutation in the MYH2 gene in a symptomatic neonate with a hereditary myosin myopathy.  |  Oatmen, K., et al. 2022. J Neonatal Perinatal Med. 15: 63-68. PMID: 34459418
6. A review of core myopathy: central core disease, multiminicore disease, dusty core disease, and core-rod myopathy.  |  Ogasawara, M. and Nishino, I. 2021. Neuromuscul Disord. 31: 968-977. PMID: 34627702
7. MYH2-associated myopathy caused by a novel splice-site variant.  |  Cassini, TA., et al. 2023. Neuromuscul Disord. 33: 257-262. PMID: 36774715
8. MYH2-related Myopathy: Expanding the Clinical Spectrum of Chronic Progressive External Ophthalmoplegia (CPEO).  |  Baskar, D., et al. 2023. J Neuromuscul Dis. 10: 727-730. PMID: 37154181
9. Indoxyl sulfate inhibits muscle cell differentiation via Myf6/MRF4 and MYH2 downregulation.  |  Bataille, S., et al. 2023. Nephrol Dial Transplant. 39: 103-113. PMID: 37349959
10. Non-muscle myosin 2 can incorporate into established filaments in cells without an assembly competence domain.  |  Wu, K., et al. 2024. bioRxiv.. PMID: 39026829

The preferred antibody is Antibody (): sc-32732m.