MYH11 Antibody (I-5): sc-65734
- MYH11 Antibody (I-5) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against crude smooth muscle extract from uterus myometrium of human origin
- Anti-MYH11 Antibody (I-5) is recommended for detection of myosin heavy chain 11 isoforms SM-1 and SM-2 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-MYH11 Antibody (I-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MYH11 Antibody (I-5) for WB and IHC(P) applications. These reagents are now offered in bundles with MYH11 Antibody (I-5) (see ordering information below).
MYH11 Antibody (I-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects myosin heavy chain 11 from mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. MYH11 (I-5) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Anti-MYH11 antibody (I-5) was raised against crude smooth muscle extract from uterus myometrium of human origin. Myosin heavy chain 11 plays a crucial role in smooth muscle contraction as a key component of the contractile apparatus that interacts with actin filaments to facilitate muscle movement. Myosin heavy chain 11′s structure consists of two heavy chain subunits and associated light chains, forming a hexameric complex essential for motor function. Heavy chains encoded by the MYH gene family exhibit actin-activated ATPase activity, vital for generating force necessary for muscle contraction. Differential expression of myosin heavy chain isoforms, such as SM-1 and SM-2, enables functional specialization of smooth muscle, allowing precise regulation of contraction in response to physiological stimuli. Understanding myosin heavy chain 11′s structure and function helps elucidate mechanisms underlying smooth muscle physiology and pathophysiology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MYH11 Antibody (I-5) References:
- Acute myeloid leukaemia (FAB AML-M4Eo) with cryptic insertion of cbfb resulting in cbfb-Myh11 fusion. | Douet-Guilbert, N., et al. 2017. Hematol Oncol. 35: 385-389. PMID: 28906004
- Myh11 Lineage Corneal Endothelial Cells and ASCs Populate Corneal Endothelium. | Corliss, BA., et al. 2019. Invest Ophthalmol Vis Sci. 60: 5095-5103. PMID: 31826231
- Clinical and prognostic significance of MYH11 in lung cancer. | Nie, MJ., et al. 2020. Oncol Lett. 19: 3899-3906. PMID: 32382337
- LncRNA Sox2ot modulates the progression of thoracic aortic aneurysm by regulating miR-330-5p/Myh11. | Xiao, W., et al. 2020. Biosci Rep. 40: PMID: 32578852
- Association of gene polymorphisms in MYH11 and TGF-β signaling with the susceptibility and clinical outcomes of DeBakey type III aortic dissection. | Chang, Y., et al. 2022. Mamm Genome. 33: 555-563. PMID: 34729648
- Molecular dissection of a hyper-aggressive CBFB-MYH11/FLT3-ITD-positive acute myeloid leukemia. | Lo Iudice, G., et al. 2022. J Transl Med. 20: 311. PMID: 35794567
- [Molecular Genetic Characteristics of Acute Myeloid Leukemia Patients with CBFβ-MYH11 Positive]. | Jiang, Y., et al. 2022. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 30: 1661-1667. PMID: 36476886
- A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury. | Bi, R., et al. 2023. Nat Commun. 14: 830. PMID: 36788226
- Characterization of leukemia progression in the Cbfb-MYH11 knockin mice by single cell RNA sequencing. | Diemer, JL., et al. 2023. Leukemia. 37: 1549-1553. PMID: 37225965
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYH11 Antibody (I-5) | sc-65734 | 200 µg/ml | $322.00 | |||
MYH11 Antibody (I-5): m-IgG Fc BP-HRP Bundle | sc-528644 | 200 µg Ab; 10 µg BP | $361.00 | |||
MYH11 Antibody (I-5): m-IgGκ BP-HRP Bundle | sc-521081 | 200 µg Ab, 40 µg BP | $361.00 | |||
MYH11 Antibody (I-5): m-IgG1 BP-HRP Bundle | sc-543049 | 200 µg Ab; 20 µg BP | $361.00 | |||
MYH11 Antibody (I-5) AC | sc-65734 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MYH11 Antibody (I-5) HRP | sc-65734 HRP | 200 µg/ml | $322.00 | |||
MYH11 Antibody (I-5) FITC | sc-65734 FITC | 200 µg/ml | $336.00 | |||
MYH11 Antibody (I-5) PE | sc-65734 PE | 200 µg/ml | $349.00 | |||
MYH11 Antibody (I-5) Alexa Fluor® 488 | sc-65734 AF488 | 200 µg/ml | $364.00 | |||
MYH11 Antibody (I-5) Alexa Fluor® 546 | sc-65734 AF546 | 200 µg/ml | $364.00 | |||
MYH11 Antibody (I-5) Alexa Fluor® 594 | sc-65734 AF594 | 200 µg/ml | $364.00 | |||
MYH11 Antibody (I-5) Alexa Fluor® 647 | sc-65734 AF647 | 200 µg/ml | $364.00 | |||
MYH11 Antibody (I-5) Alexa Fluor® 680 | sc-65734 AF680 | 200 µg/ml | $364.00 | |||
MYH11 Antibody (I-5) Alexa Fluor® 790 | sc-65734 AF790 | 200 µg/ml | $364.00 |