MyD88 Antibody (B-1): sc-136970
- MyD88 Antibody (B-1) is a mouse monoclonal IgG2a κ, cited in 30 publications, provided at 200 µg/ml
- raised against amino acids 1-296 of MyD88 of human origin
- MyD88 Antibody (B-1) is recommended for detection of MyD88 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MyD88 Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MyD88 Antibody (B-1) for WB and IHC(P) applications. These reagents are now offered in bundles with MyD88 Antibody (B-1) (see ordering information below).
QUICK LINKS
SEE ALSO...
MyD88 Antibody (B-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects MyD88 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MyD88 (B-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MyD88 plays a crucial role in the immune response by acting as an adaptor protein that facilitates the signaling cascade initiated by the interleukin-1 receptor, leading to the activation of the NFκB pathway. This pathway is vital for the transcription of pro-inflammatory cytokines and other immune mediators, which are essential for mounting an effective immune response. MyD88 structure includes a distinctive N-terminal death domain that is critical for interaction with interleukin-1 receptor-associated kinase (IRAK) and an adjacent Toll/IL-1R homology domain (TIR domain) that mediates protein-protein interactions within the receptor complex. Proper functioning of MyD88 is essential for the innate immune system, and dysregulation of MyD88 signaling can lead to various inflammatory diseases and conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MyD88 Antibody (B-1) References:
- MyD88 and its divergent toll in carcinogenesis. | Salcedo, R., et al. 2013. Trends Immunol. 34: 379-89. PMID: 23660392
- MyD88 in Mycobacterium tuberculosis infection. | Cervantes, JL. 2017. Med Microbiol Immunol. 206: 187-193. PMID: 28220253
- MyD88 as a therapeutic target for inflammatory lung diseases. | Di Padova, F., et al. 2018. Expert Opin Ther Targets. 22: 401-408. PMID: 29658361
- MYD88 L265P Mutation in Lymphoid Malignancies. | Yu, X., et al. 2018. Cancer Res. 78: 2457-2462. PMID: 29703722
- B cell-intrinsic Myd88 regulates disease progression in murine lupus. | Tilstra, JS., et al. 2023. J Exp Med. 220: PMID: 37787782
- Targeting MyD88: Therapeutic mechanisms and potential applications of the specific inhibitor ST2825. | Liu, M., et al. 2023. Inflamm Res. 72: 2023-2036. PMID: 37814128
- Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis. | Xie, B., et al. 2023. Sci Rep. 13: 22552. PMID: 38110638
- MyD88 signaling pathways: role in breast cancer. | Zheng, H., et al. 2024. Front Oncol. 14: 1336696. PMID: 38347830
- Gut microbiota regulates host melatonin production through epithelial cell MyD88. | Liu, B., et al. 2024. Gut Microbes. 16: 2313769. PMID: 38353638
- OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation. | Liu, Y., et al. 2024. Cell Death Differ. 31: 753-767. PMID: 38605168
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MyD88 Antibody (B-1) | sc-136970 | 200 µg/ml | $322.00 | |||
MyD88 Antibody (B-1): m-IgG Fc BP-HRP Bundle | sc-528831 | 200 µg Ab; 10 µg BP | $361.00 | |||
MyD88 Antibody (B-1): m-IgGκ BP-HRP Bundle | sc-521379 | 200 µg Ab, 40 µg BP | $361.00 | |||
MyD88 Antibody (B-1) AC | sc-136970 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MyD88 Antibody (B-1) HRP | sc-136970 HRP | 200 µg/ml | $322.00 | |||
MyD88 Antibody (B-1) FITC | sc-136970 FITC | 200 µg/ml | $336.00 | |||
MyD88 Antibody (B-1) PE | sc-136970 PE | 200 µg/ml | $349.00 | |||
MyD88 Antibody (B-1) Alexa Fluor® 488 | sc-136970 AF488 | 200 µg/ml | $364.00 | |||
MyD88 Antibody (B-1) Alexa Fluor® 546 | sc-136970 AF546 | 200 µg/ml | $364.00 | |||
MyD88 Antibody (B-1) Alexa Fluor® 594 | sc-136970 AF594 | 200 µg/ml | $364.00 | |||
MyD88 Antibody (B-1) Alexa Fluor® 647 | sc-136970 AF647 | 200 µg/ml | $364.00 | |||
MyD88 Antibody (B-1) Alexa Fluor® 680 | sc-136970 AF680 | 200 µg/ml | $364.00 | |||
MyD88 Antibody (B-1) Alexa Fluor® 790 | sc-136970 AF790 | 200 µg/ml | $364.00 |