MuRF2 Antibody (1A1): sc-517149

MuRF2 Antibody (1A1) is a mouse monoclonal IgG1 kappa light chain antibody that detects MuRF2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MuRF2 antibody (1A1) is available as a non-conjugated monoclonal isotype antibody. MuRF2 protein, also known as Tripartite motif containing 55, plays a crucial role in muscle physiology by regulating gene expression and protein turnover, which is essential for maintaining muscle integrity and function. MuRF2 protein is primarily located in the cytoplasm of muscle cells, but under conditions of muscle atrophy, translocates to the nucleus, highlighting a dynamic role in cellular signaling and adaptation. MuRF2 is part of a specific class of RING finger proteins expressed in striated muscle tissues, which also includes MuRF1 and MuRF3. These proteins contain a conserved N-terminal RING domain and a zinc-binding B-box motif, along with two coiled-coil motifs that facilitate protein-protein interactions. MuRF2 can oligomerize with other proteins such as titin and myosin during sarcomere assembly, and associates with the sarcomeric M-band in cardiomyocytes, underscoring its importance in muscle structure and function. At least four isoforms of MuRF2 exist, each potentially contributing to diverse regulatory roles in muscle cells.

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MuRF2 Antibody (1A1) References:

1. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.  |  Centner, T., et al. 2001. J Mol Biol. 306: 717-26. PMID: 11243782
2. Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein.  |  Pizon, V., et al. 2002. J Cell Sci. 115: 4469-82. PMID: 12414993
3. Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development.  |  McElhinny, AS., et al. 2004. J Cell Sci. 117: 3175-88. PMID: 15199100
4. The kinase domain of titin controls muscle gene expression and protein turnover.  |  Lange, S., et al. 2005. Science. 308: 1599-603. PMID: 15802564
5. Muscle disease: a giant feels the strain.  |  Tskhovrebova, L. and Trinick, J. 2005. Nat Med. 11: 478-9. PMID: 15875052
6. MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.  |  Witt, SH., et al. 2005. J Mol Biol. 350: 713-22. PMID: 15967462

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MuRF2 Antibody (1A1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MuRF2 Antibody (1A1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MuRF2 Antibody (1A1) Specifications

Alternate Product Name: TRIM55

Product Clone Name: 1A1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-452

Epitope Target: MuRF2

Epitope Species: human

Product Reactivity/Detection: MuRF2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MuRF2 Antibody (1A1): N/A