MuRF1 Antibody (D-5): sc-514767

MuRF1 Antibody (D-5) is a mouse monoclonal IgG2a antibody that detects MuRF1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MuRF1, or muscle-specific RING finger protein 1, plays a crucial role in muscle atrophy by regulating the ubiquitin-proteasome pathway, which is essential for protein degradation in skeletal muscle. MuRF1 (D-5) antibody targets proteins primarily located in the sarcomere, the fundamental unit of muscle contraction, where MuRF1 is involved in the turnover of muscle proteins during atrophy. MuRF1′s localization in the sarcomere is significant because this positioning allows for targeted degradation of specific muscle proteins, thereby facilitating the remodeling of muscle tissue in response to stress or injury. Furthermore, MuRF1′s interaction with various signaling pathways, including the IKKbeta/NF-kappaB pathway, underscores MuRF1′s importance in muscle health and disease, making anti-MuRF1 antibody (D-5) a valuable tool for therapeutic interventions aimed at combating muscle wasting conditions. MuRF1 (D-5) monoclonal antibody serves as an essential tool for researchers studying muscle biology and the molecular mechanisms underlying muscle atrophy and hypertrophy.

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MuRF1 Antibody (D-5) References:

1. GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1.  |  Yamamoto, D., et al. 2008. Life Sci. 82: 460-6. PMID: 18191156
2. Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.  |  Parry, TL., et al. 2016. Cardiovasc Pathol. 25: 127-140. PMID: 26764147
3. UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension.  |  Polge, C., et al. 2016. Int J Biochem Cell Biol. 79: 488-493. PMID: 27378730
4. Excessive glucocorticoid-induced muscle MuRF1 overexpression is independent of Akt/FoXO1 pathway.  |  Wang, XJ., et al. 2017. Biosci Rep. 37: PMID: 29046370
5. MiR-29ab1 Cluster Resists Muscle Atrophy Through Inhibiting MuRF1.  |  Liu, C., et al. 2021. DNA Cell Biol. 40: 1167-1176. PMID: 34255539
6. UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.  |  Peris-Moreno, D., et al. 2021. Cells. 10: PMID: 34440743
7. Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits.  |  Lindqvist, J., et al. 2022. Int J Mol Sci. 23: PMID: 35897687
8. Uncovering the mechanisms of MuRF1-induced ubiquitylation and revealing similarities with MuRF2 and MuRF3.  |  Lord, SO., et al. 2024. Biochem Biophys Rep. 37: 101636. PMID: 38283190
9. Aminophylline Improves Ventilator-Induced Diaphragmatic Dysfunction by Targeting IGF-1-FOXO1-MURF1 Pathway.  |  Yang, L., et al. 2024. Discov Med. 36: 699-713. PMID: 38665019
10. Small-molecule mediated MuRF1 inhibition protects from doxorubicin-induced cardiac atrophy and contractile dysfunction.  |  Alves, PKN., et al. 2024. Eur J Pharmacol. 984: 177027. PMID: 39366504

The preferred MuRF1 antibody is MuRF1 Antibody (C-11): sc-398608.