Date published: 2026-4-24

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MuRF1 Activators

MuRF1 Activators are a specialized class of chemical compounds that have garnered significant attention within the realm of molecular biology and cellular physiology. These compounds are primarily known for their unique ability to modulate the activity of Muscle RING Finger 1 (MuRF1), a critical protein involved in muscle homeostasis and regulation. MuRF1 is part of the E3 ubiquitin ligase family, and its primary function is to target specific proteins within muscle cells for degradation through the ubiquitin-proteasome pathway. This process plays a pivotal role in maintaining muscle protein turnover, ensuring the removal of damaged or unnecessary proteins, and regulating muscle mass. MuRF1 Activators, therefore, refer to a class of molecules that can enhance or stimulate the activity of MuRF1, potentially leading to increased protein degradation and, by extension, influencing muscle growth and maintenance.

The intricate regulation of MuRF1 activity by these activators has sparked significant interest in understanding their mechanisms of action and potential applications. Researchers have been investigating the molecular interactions between MuRF1 Activators and the MuRF1 protein, aiming to elucidate the pathways through which these compounds influence muscle protein turnover. This class of chemicals has the potential to shed light on fundamental processes governing muscle physiology and could have implications for a range of fields, including exercise science, aging research, and muscle-related disorders.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$91.00
$139.00
$374.00
36
(1)

Induces murf1 expression via glucocorticoid receptor

Angiotensin II, Human

4474-91-3sc-363643
sc-363643A
sc-363643B
sc-363643C
1 mg
5 mg
25 mg
100 mg
$51.00
$100.00
$310.00
$690.00
3
(1)

Upregulates murf1 via MAPK signaling pathway

Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$31.00
$61.00
$95.00
28
(1)

Induces oxidative stress leading to murf1 expression

Lipopolysaccharide, E. coli O55:B5

93572-42-0sc-221855
sc-221855A
sc-221855B
sc-221855C
10 mg
25 mg
100 mg
500 mg
$98.00
$171.00
$425.00
$1560.00
12
(2)

Activates TLR4 signaling pathway for murf1 induction

Adenosine 3′,5′-cyclic monophosphate

60-92-4sc-217584
sc-217584A
sc-217584B
sc-217584C
sc-217584D
sc-217584E
100 mg
250 mg
5 g
10 g
25 g
50 g
$116.00
$179.00
$265.00
$369.00
$629.00
$1150.00
(1)

Modulates cAMP/PKA pathway leading to murf1 expression

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Modulates RAR/RXR pathway to induce murf1 expression