Munc13-4 Antibody (C-12): sc-271301

Munc13-4 Antibody (C-12) is a mouse monoclonal IgG2a antibody that detects Munc13-4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Munc13-4 is a crucial member of the Munc13 family, functioning primarily as a peripheral membrane protein that binds to GTP-Rab 27a, facilitating the fusion of secretory lysosomes. Munc13-4 is predominantly expressed in non-neuronal tissues, with high levels found in mucous goblet cells and alveolar type II cells of the lung, as well as in cytotoxic T lymphocytes and mast cells. The localization of Munc13-4 to secretory lysosomes is significant because Munc13-4 plays a vital role in the regulation of exocytosis, particularly in the degranulation process of mast cells, which is essential for immune responses. Notably, mutations in the Munc13-4 gene are linked to familial hemophagocytic lymphohistiocytosis subtype 3, underscoring Munc13-4′s importance in immune system function and the potential consequences of dysregulation. Anti-Munc13-4 antibody (C-12) is an invaluable tool for researchers studying the mechanisms of exocytosis and the pathophysiology of related diseases.

The preferred Munc13-4 antibody is Munc13-4 Antibody (C-2): sc-271300.