Mucin 5AC/MUC5AC Antibody (CLH2): sc-33667

Mucin 5AC Antibody (CLH2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mucin 5AC of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Mucin 5AC antibody (CLH2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mucin 5AC is a crucial gel-forming mucin secreted by surface mucous cells, playing a vital role in protecting and lubricating epithelial surfaces, particularly in respiratory and gastrointestinal tracts. Mucin 5AC′s structure, characterized by high molecular weight and complex O-linked carbohydrates, forms a protective gel-like barrier that traps pathogens and particulates, preventing infection and maintaining tissue homeostasis. Glucocorticoids regulate Mucin 5AC mRNA expression, while pro-inflammatory cytokines like interleukin-6 and tumor necrosis factor-alpha enhance Mucin 5AC secretion during chronic inflammation. Retinoic acid and thyroid hormones influence Mucin 5AC expression, highlighting Mucin 5AC′s importance in both normal physiological processes and pathological conditions. Mucin 5AC expression occurs in various tissues, including normal endocervical epithelium, small intestine, gastric cells, and ethmoid mucosa, underscoring Mucin 5AC′s significance in diverse biological contexts.

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Mucin 5AC/MUC5AC Antibody (CLH2) References:

1. Immunohistochemical analysis of pyloric gland adenomas using a series of Mucin 2, Mucin 5AC, Mucin 6, CD10, Ki67 and p53.  |  Vieth, M., et al. 2010. Virchows Arch. 457: 529-36. PMID: 20827489
2. Interleukin-13 induces mucin 5AC production involving STAT6/SPDEF in human airway epithelial cells.  |  Yu, H., et al. 2010. Cell Commun Adhes. 17: 83-92. PMID: 21275604
3. Characterization of the human mucin 5AC promoter and its regulation by the histone acetyltransferase P300.  |  Xu, S., et al. 2019. Int J Mol Med. 43: 1263-1270. PMID: 30628655
4. IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway.  |  Lai, X., et al. 2019. Front Immunol. 10: 1682. PMID: 31379870
5. Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness.  |  Ganguly, K., et al. 2021. Cancer Res. 81: 91-102. PMID: 33127746
6. Role for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice.  |  Cho, HY., et al. 2021. Toxicol Pathol. 49: 1077-1099. PMID: 33938323
7. Mucin 5AC is significantly upregulated in exosomes from the nasal lavage fluid and may promote the expression of COX-2, VEGF and MMP-9: an implication in nasal polyp pathogenesis.  |  Wang, LF., et al. 2021. Rhinology. 59: 328-336. PMID: 34091656
8. Bee Venom Prevents Mucin 5AC Production through Inhibition of AKT and SPDEF Activation in Airway Epithelia Cells.  |  Kim, S., et al. 2021. Toxins (Basel). 13: PMID: 34822557
9. Clinicopathological Factors Affecting Mucin 1, Mucin 2, and Mucin 5AC Staining in Patients who Underwent Resection for Colorectal Cancer.  |  Anuk, T., et al. 2023. J Coll Physicians Surg Pak. 33: 335-340. PMID: 36945166
10. Plasma Bile Acid Profiling and Modulation of Secreted Mucin 5AC in Cholangiocarcinoma.  |  Danese, E., et al. 2023. Int J Mol Sci. 24: PMID: 37628976

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mucin 5AC/MUC5AC Antibody (CLH2) has 35 citations in a variety of scientific publications.

Primary antibodies like Anti-Mucin 5AC/MUC5AC Antibody (CLH2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mucin 5AC/MUC5AC Antibody (CLH2) Specifications

Alternate Product Name: MUC5AC

Product Clone Name: CLH2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Mucin 5AC

Epitope Species: human

Product Reactivity/Detection: Mucin 5AC

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 35 citations in various scientific publications

Available Conjugates/Forms for Mucin 5AC/MUC5AC Antibody (CLH2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Mucin 5AC/MUC5AC antibody is Mucin 5AC/MUC5AC Antibody (45M1): sc-21701.