Mucin 16/MUC16 Antibody (C-6): sc-365002
- Mucin 16/MUC16 Antibody (C-6) is a mouse monoclonal IgG2a κ Mucin 16/MUC16 antibody, cited in 10 publications, provided at 200 µg/ml
- raised against amino acids 6419-6568 mapping near the C-terminus of Mucin 16 of human origin
- Mucin 16/MUC16 Antibody (C-6) is recommended for detection of Mucin 16 of human origin by WB, IP, IF and ELISA
- Anti-Mucin 16/MUC16 Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Mucin 16/MUC16 Antibody (C-6) for WB applications. These reagents are now offered in bundles with Mucin 16/MUC16 Antibody (C-6) (see ordering information below).
Mucin 16 Antibody (C-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects Mucin 16 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Mucin 16 antibody (C-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mucin 16, also known as CA125, is a high molecular weight glycoprotein that plays a critical role in protecting and maintaining epithelial tissues. Mucin 16 (C-6) monoclonal antibody recognizes proteins primarily located on the cell surface, involved in forming protective barriers against pathogens and environmental damage. This localization enables cell signaling and adhesion, vital for maintaining tissue integrity and facilitating communication between cells. Mucin 16 serves as a significant tumor marker for monitoring ovarian cancer progression. Anti-Mucin 16 antibody (C-6) targets a protein composed of three distinct domains: a carboxy terminal domain, an extracellular domain, and an amino terminal domain, contributing to structural complexity and functional versatility. Mucin 16′s presence in the glycocalyx, a protective layer on epithelial cells, highlights its importance in immune response and cellular interactions, making Mucin 16 (C-6) antibody valuable for research and clinical applications in cancer diagnostics and therapeutic monitoring.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Mucin 16/MUC16 Antibody (C-6) References:
- Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. | Yin, BW. and Lloyd, KO. 2001. J Biol Chem. 276: 27371-5. PMID: 11369781
- Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16). | Maeda, T., et al. 2004. J Biol Chem. 279: 13174-82. PMID: 14764598
- Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer. | McLemore, MR. and Aouizerat, B. 2005. Biol Res Nurs. 6: 262-7. PMID: 15788735
- Identification of a Mu-9 (anti-colon-specific antigen-p)-reactive peptide having homology to CA125 (MUC16). | Modrak, DE., et al. 2005. Int J Oncol. 26: 1591-6. PMID: 15870874
- The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins. | Palmai-Pallag, T., et al. 2005. FEBS J. 272: 2901-11. PMID: 15943821
- Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. | Hori, Y., et al. 2005. Invest Ophthalmol Vis Sci. 46: 4050-61. PMID: 16249480
- Mucin 16 and kallikrein 13 as potential prognostic factors in colon cancer: Results of an oncological 92-multiplex immunoassay. | Björkman, K., et al. 2019. Tumour Biol. 41: 1010428319860728. PMID: 31264534
- Exosomal CA125 as A Promising Biomarker for Ovarian Cancer Diagnosis. | Chen, Z., et al. 2020. J Cancer. 11: 6445-6453. PMID: 33033528
- The evolving role of MUC16 (CA125) in the transformation of ovarian cells and the progression of neoplasia. | Giamougiannis, P., et al. 2021. Carcinogenesis. 42: 327-343. PMID: 33608706
- Ovarian Cancer Ascites Inhibits Transcriptional Activation of NK Cells Partly through CA125. | Fraser, CC., et al. 2022. J Immunol. 208: 2227-2238. PMID: 35396222
- LDH, CA125, and CYFRA21-1 in tuberculous pleural effusion. | Naranjo San Miguel, A. 2022. Med Clin (Barc). 159: e29. PMID: 35644629
- Risk-stratified CA125 screening integrating CA125 trajectories, trajectory-specific progression and transvaginal ultrasound for ovarian cancer. | Duan, H., et al. 2024. J Ovarian Res. 17: 210. PMID: 39462415
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mucin 16/MUC16 Antibody (C-6) | sc-365002 | 200 µg/ml | $316.00 | |||
Mucin 16/MUC16 Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-529299 | 200 µg Ab; 10 µg BP | $354.00 | |||
Mucin 16/MUC16 Antibody (C-6): m-IgGκ BP-HRP Bundle | sc-522117 | 200 µg Ab, 40 µg BP | $354.00 | |||
Mucin 16/MUC16 Antibody (C-6) AC | sc-365002 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Mucin 16/MUC16 Antibody (C-6) HRP | sc-365002 HRP | 200 µg/ml | $316.00 | |||
Mucin 16/MUC16 Antibody (C-6) FITC | sc-365002 FITC | 200 µg/ml | $330.00 | |||
Mucin 16/MUC16 Antibody (C-6) PE | sc-365002 PE | 200 µg/ml | $343.00 | |||
Mucin 16/MUC16 Antibody (C-6) Alexa Fluor® 488 | sc-365002 AF488 | 200 µg/ml | $357.00 | |||
Mucin 16/MUC16 Antibody (C-6) Alexa Fluor® 546 | sc-365002 AF546 | 200 µg/ml | $357.00 | |||
Mucin 16/MUC16 Antibody (C-6) Alexa Fluor® 594 | sc-365002 AF594 | 200 µg/ml | $357.00 | |||
Mucin 16/MUC16 Antibody (C-6) Alexa Fluor® 647 | sc-365002 AF647 | 200 µg/ml | $357.00 | |||
Mucin 16/MUC16 Antibody (C-6) Alexa Fluor® 680 | sc-365002 AF680 | 200 µg/ml | $357.00 | |||
Mucin 16/MUC16 Antibody (C-6) Alexa Fluor® 790 | sc-365002 AF790 | 200 µg/ml | $357.00 |