Mucin 13/MUC13 Antibody (D-5): sc-373857

Mucin 13 Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mucin 13 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Mucin 13 (D-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mucin 13, also known as down-regulated in colon cancer 1 (DRCC1), is an important epithelial and hemopoietic type I membrane protein that plays a crucial role in maintaining gastrointestinal mucosa integrity. Mucin 13 primarily localizes to the apical membrane of columnar and goblet cells within the gastrointestinal tract, contributing to the protective mucosal barrier and facilitating cell signaling. Mucin 13 expression serves as a differentiation marker for gastrointestinal mucosa and may indicate certain gastric tumors. Mucin 13 undergoes post-translational modifications, including glycosylation, essential for function and stability, influencing protein interactions and overall role in cellular processes. Mucin 13 homodimerizes through its β subunit, containing the cytoplasmic tail, highlighting significance in cellular signaling pathways and potential cancer biology implications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Mucin 13/MUC13 Antibody (D-5) References:

1. Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells.  |  Williams, SJ., et al. 2001. J Biol Chem. 276: 18327-36. PMID: 11278439
2. Cell signaling through membrane mucins.  |  Carraway, KL., et al. 2003. Bioessays. 25: 66-71. PMID: 12508284
3. [Normal human conjunctival epithelium expresses MUC13, MUC15, MUC16 and MUC17 mucin genes].  |  Corrales, RM., et al. 2003. Arch Soc Esp Oftalmol. 78: 375-81. PMID: 12898407
4. Mucins in cancer: protection and control of the cell surface.  |  Hollingsworth, MA. and Swanson, BJ. 2004. Nat Rev Cancer. 4: 45-60. PMID: 14681689
5. Mucins and mucin binding proteins in colorectal cancer.  |  Byrd, JC. and Bresalier, RS. 2004. Cancer Metastasis Rev. 23: 77-99. PMID: 15000151
6. Expression of the cell surface mucin gene family in adenocarcinomas.  |  Packer, LM., et al. 2004. Int J Oncol. 25: 1119-26. PMID: 15375564
7. Overexpression of MUC13 is associated with intestinal-type gastric cancer.  |  Shimamura, T., et al. 2005. Cancer Sci. 96: 265-73. PMID: 15904467
8. Mucin 13: structure, function, and potential roles in cancer pathogenesis.  |  Maher, DM., et al. 2011. Mol Cancer Res. 9: 531-537. PMID: 21450906
9. The expression and prognostic significance of Mucin 13 and Mucin 20 in esophageal squamous cell carcinoma.  |  Wang, H., et al. 2015. J Cancer Res Ther. 11 Suppl 1: C74-9. PMID: 26323930
10. Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases.  |  Filippou, PS., et al. 2018. Clin Chem Lab Med. 56: 1945-1953. PMID: 29768245
11. Mucin 13 (MUC13) as a candidate biomarker for ovarian cancer detection: potential to complement CA125 in detecting non-serous subtypes.  |  Ren, AH., et al. 2023. Clin Chem Lab Med. 61: 464-472. PMID: 36380677
12. Low Expression of Mucin 2, High Expression of Mucin 13, and High Expression of Nuclear Factor Kappa-Light-Enhancer of Activated B Cells were Significant Pathways in Colorectal Cancer Development.  |  Mulyawan, IM. 2023. Asian Pac J Cancer Prev. 24: 1119-1123. PMID: 37116131

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mucin 13/MUC13 Antibody (D-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Mucin 13/MUC13 Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mucin 13/MUC13 Antibody (D-5) Specifications

Alternate Product Name: MUC13

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 19-318

Epitope Target: Mucin 13

Epitope Species: human

Product Reactivity/Detection: Mucin 13

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Mucin 13/MUC13 Antibody (D-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Mucin 13/MUC13 antibody is Mucin 13/MUC13 Antibody (G-10): sc-390115.