Mucin 12/MUC12 Antibody (G-1): sc-377268

Mucin 12 Antibody (G-1) is a mouse monoclonal IgG2a antibody that detects Mucin 12 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mucin 12 is a high molecular weight glycoprotein that plays a crucial role in forming the protective mucosal barrier, essential for safeguarding epithelial tissues from pathogens and particulate matter. Anti-Mucin 12 antibody (G-1) recognizes unique structural features, including a predicted transmembrane domain, two extracellular cysteine-rich epidermal growth factor-like domains, and a coiled-coil region, along with a domain rich in serine, threonine, and proline that consists of degenerate tandem repeats. These structural elements are vital for Mucin 12′s function, as they contribute to stability and interaction with other molecules in the extracellular matrix. Mucin 12 is predominantly expressed in the colon, pancreas, prostate, and uterus, and transcript levels can be significantly reduced in colorectal tumors compared to normal colon tissues, highlighting potential as a biomarker for cancer diagnostics. Mucin 12 monoclonal antibody (G-1) serves as an invaluable tool for researchers studying mucin biology and implications in various diseases, particularly in understanding the role of mucins in tumor progression and maintenance of epithelial integrity.

The preferred Mucin 12/MUC12 antibody is Mucin 12/MUC12 Antibody (B-9): sc-377269.