Mucin 12/MUC12 Antibody (B-9): sc-377269
- Mucin 12/MUC12 Antibody (B-9) is a mouse monoclonal IgG1 κ Mucin 12/MUC12 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 61-360 mapping near the N-terminus of Mucin 12 of human origin
- Mucin 12/MUC12 Antibody (B-9) is recommended for detection of Mucin 12 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Mucin 12/MUC12 Antibody (B-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Mucin 12/MUC12 Antibody (B-9) for WB and IHC(P) applications. These reagents are now offered in bundles with Mucin 12/MUC12 Antibody (B-9) (see ordering information below).
Mucin 12 Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mucin 12 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Mucin 12 antibody (B-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mucin 12 is a high molecular weight glycoprotein that plays a crucial role in protecting mucosal surfaces, contributing to the formation of a protective barrier against pathogens and particulate matter. Mucin 12 is primarily located in epithelial cells of the colon, pancreas, prostate, and uterus, where Mucin 12 maintains the integrity of the mucosal layer. Expression of Mucin 12 in these tissues is vital for proper physiological function, as Mucin 12 helps prevent inflammation and infection by trapping harmful substances. Studies have shown that colorectal tumors often exhibit reduced levels of Mucin 12 transcript compared to normal colon tissues, suggesting Mucin 12′s potential role as a biomarker for cancer progression. Mucin 12 contains a predicted transmembrane domain, two extracellular cysteine-rich EGF-like domains, a coiled-coil region, and a domain rich in serine, threonine, and proline, which are characteristic features of mucins that contribute to their structural and functional diversity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Mucin 12/MUC12 Antibody (B-9) References:
- Two novel mucin genes down-regulated in colorectal cancer identified by differential display. | Williams, SJ., et al. 1999. Cancer Res. 59: 4083-9. PMID: 10463611
- Histochemical alterations of mucin in normal colon, inflammatory bowel disease and colonic adenocarcinoma. | Owen, DA. and Reid, PE. 1995. Histochem J. 27: 882-9. PMID: 8787966
- Regulation of mucin MUC2 gene expression during colon carcinogenesis. | Gratchev, A., et al. 1998. Ann N Y Acad Sci. 859: 180-3. PMID: 9928381
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mucin 12/MUC12 Antibody (B-9) | sc-377269 | 200 µg/ml | $316.00 | |||
Mucin 12/MUC12 Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-523258 | 200 µg Ab, 40 µg BP | $354.00 | |||
Mucin 12/MUC12 Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-533567 | 200 µg Ab; 20 µg BP | $354.00 | |||
Mucin 12/MUC12 Antibody (B-9) AC | sc-377269 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Mucin 12/MUC12 Antibody (B-9) HRP | sc-377269 HRP | 200 µg/ml | $316.00 | |||
Mucin 12/MUC12 Antibody (B-9) FITC | sc-377269 FITC | 200 µg/ml | $330.00 | |||
Mucin 12/MUC12 Antibody (B-9) PE | sc-377269 PE | 200 µg/ml | $343.00 | |||
Mucin 12/MUC12 Antibody (B-9) Alexa Fluor® 488 | sc-377269 AF488 | 200 µg/ml | $357.00 | |||
Mucin 12/MUC12 Antibody (B-9) Alexa Fluor® 546 | sc-377269 AF546 | 200 µg/ml | $357.00 | |||
Mucin 12/MUC12 Antibody (B-9) Alexa Fluor® 594 | sc-377269 AF594 | 200 µg/ml | $357.00 | |||
Mucin 12/MUC12 Antibody (B-9) Alexa Fluor® 647 | sc-377269 AF647 | 200 µg/ml | $357.00 | |||
Mucin 12/MUC12 Antibody (B-9) Alexa Fluor® 680 | sc-377269 AF680 | 200 µg/ml | $357.00 | |||
Mucin 12/MUC12 Antibody (B-9) Alexa Fluor® 790 | sc-377269 AF790 | 200 µg/ml | $357.00 |