MTO1 Antibody (A-8): sc-398760

MTO1 Antibody (A-8) is a mouse monoclonal IgG1 antibody that detects MTO1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MTO1, also known as CGI-02, is a 717 amino acid mitochondrial protein that plays a crucial role in mitochondrial tRNA modification, specifically facilitating the 5-carboxymethylaminomethyl modification of wobble uridine bases. This modification is essential for the accurate translation of mitochondrial mRNA, which is vital for the synthesis of proteins that are integral to mitochondrial function and energy production. The proper functioning of MTO1 is particularly important in tissues with high metabolic rates, where mitochondrial activity is critical for cellular energy demands. Furthermore, MTO1 is implicated in the expression of phenotypes associated with aminoglycoside-induced and non-syndromic deafness due to mutations in the 12S rRNA gene, highlighting its potential role in the pathogenesis of these conditions. MTO1 is known to exist in multiple isoforms generated by alternative splicing, which may contribute to its functional diversity and regulatory mechanisms within the cell. Anti-MTO1 antibody (A-8) is an invaluable tool for researchers studying mitochondrial biology and related disorders.

The preferred MTO1 antibody is MTO1 Antibody (H-5): sc-398386.