MTMR4 Antibody (D-5): sc-373922
- MTMR4 Antibody (D-5) is a mouse monoclonal IgG2b κ MTMR4 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-23 at the N-terminus of MTMR4 of human origin
- MTMR4 Antibody (D-5) is recommended for detection of MTMR4 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine, porcine and avian
- Anti-MTMR4 Antibody (D-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MTMR4 Antibody (D-5) for WB and IHC(P) applications. These reagents are now offered in bundles with MTMR4 Antibody (D-5) (see ordering information below).
MTMR4 Antibody (D-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects MTMR4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MTMR4 (D-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MTMR4 protein is part of the myotubularin family, which consists of highly conserved eukaryotic phosphatases that play a crucial role in cellular signaling by hydrolyzing inositol phospholipids, specifically Phosphatidylinositol 3-phosphate and Phosphatidylinositol (3,5) bisphosphate. This enzymatic activity is vital for regulating membrane trafficking and cellular processes such as autophagy and endocytosis. MTMR4 interacts with other members of the MTMR family, including MTMR2 and MTMR3, which can influence localization and function within the cell. Mutations in related proteins, such as MTMR2, have been linked to autosomal recessive Charcot-Marie-Tooth disease, highlighting the significance of these proteins in maintaining neuronal health. Anti-MTMR4 antibody (D-5) effectively detects and characterizes MTMR4 protein, making this reagent an essential tool for researchers studying the molecular mechanisms underlying these critical cellular functions and their implications in disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MTMR4 Antibody (D-5) References:
- Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway. | Blondeau, F., et al. 2000. Hum Mol Genet. 9: 2223-9. PMID: 11001925
- Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. | Kim, SA., et al. 2003. Proc Natl Acad Sci U S A. 100: 4492-7. PMID: 12668758
- Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. | Mochizuki, Y. and Majerus, PW. 2003. Proc Natl Acad Sci U S A. 100: 9768-73. PMID: 12890864
- Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. | Berger, P., et al. 2006. Hum Mol Genet. 15: 569-79. PMID: 16399794
- Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. | Lorenzo, O., et al. 2006. J Cell Sci. 119: 2953-9. PMID: 16787938
- Mutations in the MTM1 gene implicated in X-linked myotubular myopathy. ENMC International Consortium on Myotubular Myopathy. European Neuro-Muscular Center. | Laporte, J., et al. 1997. Hum Mol Genet. 6: 1505-11. PMID: 9305655
- Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. | Srivastava, S., et al. 2006. Mol Biol Cell. 17: 146-54. PMID: 16251351
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTMR4 Antibody (D-5) | sc-373922 | 200 µg/ml | $316.00 | |||
MTMR4 Antibody (D-5): m-IgG Fc BP-HRP Bundle | sc-529612 | 200 µg Ab; 10 µg BP | $354.00 | |||
MTMR4 Antibody (D-5): m-IgGκ BP-HRP Bundle | sc-522559 | 200 µg Ab, 40 µg BP | $354.00 | |||
MTMR4 Antibody (D-5): m-IgG2b BP-HRP Bundle | sc-550132 | 200 µg Ab; 10 µg BP | $354.00 | |||
MTMR4 Antibody (D-5) AC | sc-373922 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MTMR4 Antibody (D-5) HRP | sc-373922 HRP | 200 µg/ml | $316.00 | |||
MTMR4 Antibody (D-5) FITC | sc-373922 FITC | 200 µg/ml | $330.00 | |||
MTMR4 Antibody (D-5) PE | sc-373922 PE | 200 µg/ml | $343.00 | |||
MTMR4 Antibody (D-5) Alexa Fluor® 488 | sc-373922 AF488 | 200 µg/ml | $357.00 | |||
MTMR4 Antibody (D-5) Alexa Fluor® 546 | sc-373922 AF546 | 200 µg/ml | $357.00 | |||
MTMR4 Antibody (D-5) Alexa Fluor® 594 | sc-373922 AF594 | 200 µg/ml | $357.00 | |||
MTMR4 Antibody (D-5) Alexa Fluor® 647 | sc-373922 AF647 | 200 µg/ml | $357.00 | |||
MTMR4 Antibody (D-5) Alexa Fluor® 680 | sc-373922 AF680 | 200 µg/ml | $357.00 | |||
MTMR4 Antibody (D-5) Alexa Fluor® 790 | sc-373922 AF790 | 200 µg/ml | $357.00 | |||
MTMR4 (D-5) Neutralizing Peptide | sc-373922 P | 100 µg/0.5 ml | $68.00 |