MTA1 Antibody (E-12): sc-373765
- MTA1 Antibody (E-12) is a mouse monoclonal IgG2a κ MTA1 antibody, cited in 9 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 669-703 near the C-terminus of MTA1 of human origin
- MTA1 Antibody (E-12) is recommended for detection of MTA1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MTA1 Antibody (E-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MTA1 Antibody (E-12) for WB and IHC(P) applications. These reagents are now offered in bundles with MTA1 Antibody (E-12) (see ordering information below).
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MTA1 Antibody (E-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects MTA1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MTA1 monoclonal antibody (E-12) is specific for an epitope mapping between amino acids 669-703 near the C-terminus of MTA1 of human origin. Anti-MTA1 antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MTA1, known as metastasis-associated protein 1, plays a crucial role as a component of the NURD (nucleosome remodeling and histone deacetylation) complex, essential for ATP-dependent chromatin remodeling and histone deacetylase activity. Anti-MTA1 antibody (E-12) function in mediating transcriptional repression is vital for regulating gene expression, facilitating recruitment of repressor molecules to chromatin, thereby influencing cellular processes such as differentiation and proliferation. Structurally, MTA1 features a single SH3-binding motif and a zinc finger domain, along with a region homologous to the co-repressor protein N-Cor, contributing to functional versatility. MTA1 is typically expressed at low levels across various tissues, with significant elevation in testis and correlation with tumor invasion and metastasis in several carcinomas, including colorectal, gastrointestinal, and breast cancers. MTA1 overexpression in tumors is associated with enhanced lymph node metastasis, increased motility of mammary cells, and augmented tumor growth, making MTA1 a potential biomarker for assessing malignancy in various cancers. MTA1 shares over 55% sequence homology with MTA2 (MTA1-like protein 1), which is ubiquitously expressed and may also play a role in cancer progression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTA1 Antibody (E-12) | sc-373765 | 200 µg/ml | $316.00 | |||
MTA1 Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-529555 | 200 µg Ab; 10 µg BP | $354.00 | |||
MTA1 Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-522488 | 200 µg Ab, 40 µg BP | $354.00 | |||
MTA1 Antibody (E-12): m-IgG2a BP-HRP Bundle | sc-547329 | 200 µg Ab; 10 µg BP | $354.00 | |||
MTA1 Antibody (E-12) AC | sc-373765 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MTA1 Antibody (E-12) HRP | sc-373765 HRP | 200 µg/ml | $316.00 | |||
MTA1 Antibody (E-12) FITC | sc-373765 FITC | 200 µg/ml | $330.00 | |||
MTA1 Antibody (E-12) PE | sc-373765 PE | 200 µg/ml | $343.00 | |||
MTA1 Antibody (E-12) Alexa Fluor® 488 | sc-373765 AF488 | 200 µg/ml | $357.00 | |||
MTA1 Antibody (E-12) Alexa Fluor® 546 | sc-373765 AF546 | 200 µg/ml | $357.00 | |||
MTA1 Antibody (E-12) Alexa Fluor® 594 | sc-373765 AF594 | 200 µg/ml | $357.00 | |||
MTA1 Antibody (E-12) Alexa Fluor® 647 | sc-373765 AF647 | 200 µg/ml | $357.00 | |||
MTA1 Antibody (E-12) Alexa Fluor® 680 | sc-373765 AF680 | 200 µg/ml | $357.00 | |||
MTA1 Antibody (E-12) Alexa Fluor® 790 | sc-373765 AF790 | 200 µg/ml | $357.00 | |||
MTA1 (E-12) Neutralizing Peptide | sc-373765 P | 100 µg/0.5 ml | $68.00 |