MSH3 Antibody (C-8): sc-271079
- MSH3 Antibody (C-8) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 61-360 of MSH3 of human origin
- recommended for detection of MSH3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MSH3 Antibody (C-8) for WB and IHC(P) applications. These reagents are now offered in bundles with MSH3 Antibody (C-8) (see ordering information below).
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MSH3 Antibody (C-8) is a mouse monoclonal IgG2b antibody that detects MSH3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MSH3 plays a critical role in the DNA mismatch repair (MMR) pathway, which maintains genomic stability by correcting errors during DNA replication. MSH3 is primarily located in the nucleus, where MSH3 forms heterodimers with MSH2 to recognize and bind to mismatched DNA bases, facilitating their repair. MSH3′s nuclear localization is crucial for direct involvement in the repair process; any dysfunction or mislocalization can lead to mutation accumulation, contributing to genomic instability and increasing the risk of various cancers, including hereditary nonpolyposis colorectal cancer (HNPCC). MSH3′s interaction with other MMR proteins, such as MLH1 and PMS2, further underscores MSH3′s significance in the repair mechanism, as these interactions are essential for forming a functional repair complex. Anti-MSH3 antibody (C-8) serves as an invaluable tool for researchers studying DNA repair mechanisms and their implications in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MSH3 Antibody (C-8) | sc-271079 | 200 µg/ml | $322.00 | |||
MSH3 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-534866 | 200 µg Ab; 40 µg BP | $361.00 | |||
MSH3 Antibody (C-8): m-IgG2b BP-HRP Bundle | sc-549308 | 200 µg Ab; 10 µg BP | $361.00 |