MRP1 Antibody (IU2H10): sc-53130
- MRP1 Antibody (IU2H10) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against recombinant MRP1 of human origin
- Anti-MRP1 Antibody (IU2H10) is recommended for detection of MRP1 of mouse, rat and human origin by WB, IP, IF and FCM
- Anti-MRP1 Antibody (IU2H10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of MRP1 (IU2H10): sc-53130.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MRP1 Antibody (IU2H10) for WB applications. These reagents are now offered in bundles with MRP1 Antibody (IU2H10) (see ordering information below).
MRP1 Antibody (IU2H10) is a mouse monoclonal IgG1 kappa light chain antibody that detects MRP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). MRP1 Antibody (IU2H10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MRP1, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in the cellular efflux of a wide range of substrates, including drugs and endogenous compounds, thereby contributing to multidrug resistance in cancer cells. MRP1 localization as an integral membrane protein is vital, as MRP1 is predominantly expressed in various tissues such as the brain, lungs, testis, and peripheral blood, where MRP1 helps regulate the transport of organic anions and xenobiotics. The structure of MRP1 includes an Mdr-like core and a unique N-terminal membrane-bound region, which are essential for MRP1 function in mediating the transport of conjugated drugs and metabolites across cellular membranes. Understanding the structural features of MRP1 is important for developing strategies to overcome drug resistance in cancer therapy, as alterations in MRP1 expression or function can significantly impact the efficacy of chemotherapeutic agents.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP1 Antibody (IU2H10) | sc-53130 | 200 µg/ml | $316.00 | |||
MRP1 Antibody (IU2H10): m-IgG Fc BP-HRP Bundle | sc-526771 | 200 µg Ab; 10 µg BP | $354.00 | |||
MRP1 Antibody (IU2H10): m-IgG1 BP-HRP Bundle | sc-532144 | 200 µg Ab; 20 µg BP | $354.00 | |||
MRP1 Antibody (IU2H10) AC | sc-53130 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MRP1 Antibody (IU2H10) HRP | sc-53130 HRP | 200 µg/ml | $316.00 | |||
MRP1 Antibody (IU2H10) FITC | sc-53130 FITC | 200 µg/ml | $330.00 | |||
MRP1 Antibody (IU2H10) PE | sc-53130 PE | 200 µg/ml | $343.00 | |||
MRP1 Antibody (IU2H10) Alexa Fluor® 488 | sc-53130 AF488 | 200 µg/ml | $357.00 | |||
MRP1 Antibody (IU2H10) Alexa Fluor® 546 | sc-53130 AF546 | 200 µg/ml | $357.00 | |||
MRP1 Antibody (IU2H10) Alexa Fluor® 594 | sc-53130 AF594 | 200 µg/ml | $357.00 | |||
MRP1 Antibody (IU2H10) Alexa Fluor® 647 | sc-53130 AF647 | 200 µg/ml | $357.00 | |||
MRP1 Antibody (IU2H10) Alexa Fluor® 680 | sc-53130 AF680 | 200 µg/ml | $357.00 | |||
MRP1 Antibody (IU2H10) Alexa Fluor® 790 | sc-53130 AF790 | 200 µg/ml | $357.00 |