MRP-L2 Antibody (D-11): sc-398473
- MRP-L2 Antibody (D-11) is a mouse monoclonal IgG2b κ MRP-L2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 88-99 within an internal region of MRP-L2 of human origin
- MRP-L2 Antibody (D-11) is recommended for detection of MRP-L2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MRP-L2 Antibody (D-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MRP-L2 Antibody (D-11) for WB applications. These reagents are now offered in bundles with MRP-L2 Antibody (D-11) (see ordering information below).
MRP-L2 Antibody (D-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects MRP-L2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP-L2 (D-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MRP-L2, also known as CGI-22 or RPML14, is a crucial component of mitochondrial ribosomes, which are essential for protein synthesis within mitochondria. MRP-L2 consists of 305 amino acids and belongs to the ribosomal protein L2P family, playing a vital role in the assembly and function of the mitochondrial ribosome. Proper functioning of mitochondrial ribosomes is critical for cellular energy production, as these structures synthesize proteins integral to the electron transport chain and ATP generation. Notably, the gene encoding MRP-L2 is located on human chromosome 6, a region associated with various health conditions, including early onset intestinal cancer and several genetic disorders. Deletion of a portion of the q arm of chromosome 6 has been linked to cancer susceptibility, highlighting MRP-L2′s importance in both mitochondrial function and potential disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MRP-L2 Antibody (D-11) References:
- Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. | Suzuki, T., et al. 2001. J Biol Chem. 276: 21724-36. PMID: 11279069
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. | Kenmochi, N., et al. 2001. Genomics. 77: 65-70. PMID: 11543634
- Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. | Cesari, R., et al. 2003. Proc Natl Acad Sci U S A. 100: 5956-61. PMID: 12719539
- Nuclear MRP genes and mitochondrial disease. | O'Brien, TW., et al. 2005. Gene. 354: 147-51. PMID: 15908146
- Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22. | Bläker, H., et al. 2008. Genes Chromosomes Cancer. 47: 159-64. PMID: 18008368
- Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. | Fan, J., et al. 2010. Am J Med Genet B Neuropsychiatr Genet. 153B: 29-37. PMID: 19308960
- Associations among behavior-related susceptibility factors in porphyria cutanea tarda. | Jalil, S., et al. 2010. Clin Gastroenterol Hepatol. 8: 297-302, 302.e1. PMID: 19948245
- A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene. | Brunner, HG., et al. 1994. Hum Mol Genet. 3: 1561-4. PMID: 7833911
- Mitochondrial ribosomal proteins (MRPs) of yeast. | Graack, HR. and Wittmann-Liebold, B. 1998. Biochem J. 329 (Pt 3): 433-48. PMID: 9445368
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP-L2 Antibody (D-11) | sc-398473 | 200 µg/ml | $316.00 | |||
MRP-L2 Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-530814 | 200 µg Ab; 10 µg BP | $354.00 | |||
MRP-L2 Antibody (D-11): m-IgGκ BP-HRP Bundle | sc-524359 | 200 µg Ab, 40 µg BP | $354.00 | |||
MRP-L2 Antibody (D-11): m-IgG2b BP-HRP Bundle | sc-550231 | 200 µg Ab; 10 µg BP | $354.00 | |||
MRP-L2 Antibody (D-11) AC | sc-398473 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MRP-L2 Antibody (D-11) HRP | sc-398473 HRP | 200 µg/ml | $316.00 | |||
MRP-L2 Antibody (D-11) FITC | sc-398473 FITC | 200 µg/ml | $330.00 | |||
MRP-L2 Antibody (D-11) PE | sc-398473 PE | 200 µg/ml | $343.00 | |||
MRP-L2 Antibody (D-11) Alexa Fluor® 488 | sc-398473 AF488 | 200 µg/ml | $357.00 | |||
MRP-L2 Antibody (D-11) Alexa Fluor® 546 | sc-398473 AF546 | 200 µg/ml | $357.00 | |||
MRP-L2 Antibody (D-11) Alexa Fluor® 594 | sc-398473 AF594 | 200 µg/ml | $357.00 | |||
MRP-L2 Antibody (D-11) Alexa Fluor® 647 | sc-398473 AF647 | 200 µg/ml | $357.00 | |||
MRP-L2 Antibody (D-11) Alexa Fluor® 680 | sc-398473 AF680 | 200 µg/ml | $357.00 | |||
MRP-L2 Antibody (D-11) Alexa Fluor® 790 | sc-398473 AF790 | 200 µg/ml | $357.00 | |||
MRP-L2 (D-11) Neutralizing Peptide | sc-398473 P | 100 µg/0.5 ml | $68.00 |