MRE11 Antibody (18): sc-135992

MRE11 Antibody (18) is a mouse monoclonal IgG1 kappa light chain antibody that detects MRE11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-MRE11 antibody (18) is available as non-conjugated and plays a crucial role in the cellular response to DNA damage. MRE11 (18) antibody recognizes a vital component of the MRN complex, which includes RAD50 and NBS1, essential for DNA double-strand break repair through homologous recombination. MRE11 functions in the nucleus as a 3′ to 5′ exonuclease and endonuclease, facilitating DNA end processing to promote repair and maintain genomic stability. Nuclear localization ensures rapid response to DNA damage, preventing potential mutations and neoplastic transformations. MRE11 participates in telomere maintenance, highlighting significance in cellular health and longevity. MRE11 interaction with RAD50 and NBS1 enhances DNA repair pathway functionality, making MRE11 (18) monoclonal antibody valuable for cancer biology and genetic disorder studies.

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MRE11 Antibody (18) References:

1. Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.  |  Zhong, Q., et al. 2002. Cancer Res. 62: 3966-70. PMID: 12124328
2. Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre.  |  Lisby, M., et al. 2003. Nat Cell Biol. 5: 572-7. PMID: 12766777
3. In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination.  |  Sugawara, N., et al. 2003. Mol Cell. 12: 209-19. PMID: 12887906
4. In vivo assembly and disassembly of Rad51 and Rad52 complexes during double-strand break repair.  |  Miyazaki, T., et al. 2004. EMBO J. 23: 939-49. PMID: 14765116
5. The human Rap1 protein complex and modulation of telomere length.  |  O'Connor, MS., et al. 2004. J Biol Chem. 279: 28585-91. PMID: 15100233
6. DNA annealing mediated by Rad52 and Rad59 proteins.  |  Wu, Y., et al. 2006. J Biol Chem. 281: 15441-9. PMID: 16565518
7. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.  |  Bekker-Jensen, S., et al. 2006. J Cell Biol. 173: 195-206. PMID: 16618811
8. Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.  |  Zhang, T., et al. 2022. Nat Commun. 13: 5133. PMID: 36050397
9. RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.  |  Liu, W., et al. 2023. Adv Sci (Weinh). 10: e2203884. PMID: 36563124
10. Metabolic regulation of homologous recombination repair by MRE11 lactylation.  |  Chen, Y., et al. 2024. Cell. 187: 294-311.e21. PMID: 38128537
11. MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.  |  Cho, MG., et al. 2024. Nature. 625: 585-592. PMID: 38200309
12. Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae.  |  Tsukamoto, Y., et al. 1996. Genetics. 142: 383-91. PMID: 8852838

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MRE11 Antibody (18) has 21 citations in a variety of scientific publications.

Primary antibodies like Anti-MRE11 Antibody (18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MRE11 Antibody (18) Specifications

Alternate Product Name: Meiotic Recombination 11

Product Clone Name: 18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 3-194

Epitope Target: MRE11

Epitope Species: human

Product Reactivity/Detection: MRE11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 21 citations in various scientific publications

Available Conjugates/Forms for MRE11 Antibody (18): N/A