MPO light chain/Myeloperoxidase Antibody (C-3): sc-390109

MPO light chain Antibody (C-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects MPO light chain in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MPO light chain (C-3) antibody is available in both conjugated and non-conjugated forms, providing flexibility for different experimental needs. The heme protein myeloperoxidase (MPO) plays a crucial role in the immune response, primarily found in the azurophilic granules of neutrophils and polymorphonuclear leukocytes. MPO (C-3) monoclonal antibody enables research into MPO′s essential role in optimal oxygen-dependent microbiocidal activity, as MPO catalyzes the production of hypochlorous acid and other reactive oxygen species vital for pathogen destruction. MPO is synthesized during the promyelocytic stage of myeloid differentiation and undergoes post-translational modifications, including cotranslational N-linked glycosylation, critical for proper folding and function. This glycosylation process ensures MPO′s correct processing and transport to lysosomes, where MPO matures into an active form. In normal neutrophils, MPO exists as a dimer, with high expression in circulating neutrophils and monocytes, while remaining absent in microglia and normal brain tissue. MPO′s interaction with calreticulin, a calcium-binding protein in the endoplasmic reticulum, highlights the importance of post-translational modifications in MPO′s maturation and function, making anti-MPO light chain antibody (C-3) valuable for studying myeloperoxidase-related processes.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MPO light chain/Myeloperoxidase Antibody (C-3) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-MPO light chain/Myeloperoxidase Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MPO light chain/Myeloperoxidase Antibody (C-3) Specifications

Alternate Product Name: MPO light chain

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 221-259

Epitope Target: MPO

Epitope Species: mouse

Product Reactivity/Detection: MPO light chain

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for MPO light chain/Myeloperoxidase Antibody (C-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, P: Blocking Peptide, PE: Phycoerythrin

The preferred MPO/Myeloperoxidase antibody is MPO/Myeloperoxidase Antibody (266-6K1): sc-52707.