Mpi Antibody (B-2): sc-393484

Mpi Antibody (B-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mpi protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Mpi (B-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mpi protein, also known as mannose phosphate isomerase or PMI1, is a crucial 423 amino acid zinc metalloenzyme that plays a vital role in glycoprotein biosynthesis by catalyzing the interconversion of fructose-6-phosphate and mannose-6-phosphate. This enzymatic activity is essential for maintaining a steady supply of D-mannose derivatives, which are necessary for most glycosylation reactions, thereby influencing proper folding and function of glycoproteins. Mpi is predominantly expressed in heart, brain, and skeletal muscle, and cytoplasmic localization allows efficient participation in metabolic pathways. Mutations in Mpi-encoding genes can lead to congenital disorder of glycosylation type 1B (CDG1B), a condition characterized by severe developmental issues, including protein-losing enteropathy and significant mental and psychomotor retardation. Anti-Mpi antibody (B-2) detection capabilities make this reagent invaluable for researchers studying glycosylation disorders and related metabolic pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mpi Antibody (B-2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Mpi Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mpi Antibody (B-2) Specifications

Alternate Product Name: Mpi

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-164

Epitope Target: Mpi

Epitope Species: human

Product Reactivity/Detection: Mpi

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Mpi Antibody (B-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Mpi antibody is Mpi Antibody (E-4): sc-393477.