Mog1p Antibody (C-2): sc-393574

Mog1p Antibody (C-2) is a mouse monoclonal IgG2a antibody that detects Mog1p in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mog1p, also known as RanGNRF or Ran-binding protein MOG1, is a crucial 186 amino acid protein that plays a significant role in regulating intracellular trafficking of the small Ras-related protein, Ran, which is essential for various cellular processes including DNA replication and transport of RNA and proteins through the nuclear pore complex. Mog1p′s importance lies in shuttling between nucleus and cytoplasm, facilitating guanine nucleotide release from Ran, thereby influencing nuclear transport dynamics. Mog1p exists as four isoforms generated by alternative splicing, with isoforms one and two being ubiquitously expressed, highlighting Mog1p′s versatility and potential regulatory mechanisms in different cellular contexts. Additionally, Mog1p interacts with other proteins such as Ran and Na+ CP type Vα, as well as forming complexes with Ran and Ran BP-1, underscoring Mog1p′s integral role in cellular signaling pathways and transport processes. Anti-Mog1p antibody (C-2) is an invaluable tool for researchers aiming to explore functional dynamics of Mog1p in various biological systems.

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Mog1p Antibody (C-2) References:

1. The mammalian Mog1 protein is a guanine nucleotide release factor for Ran.  |  Steggerda, SM. and Paschal, BM. 2000. J Biol Chem. 275: 23175-80. PMID: 10811801
2. 1.9 A resolution crystal structure of the Saccharomyces cerevisiae Ran-binding protein Mog1p.  |  Stewart, M. and Baker, RP. 2000. J Mol Biol. 299: 213-23. PMID: 10860733
3. Yrb1p interaction with the gsp1p C terminus blocks Mog1p stimulation of GTP release from Gsp1p.  |  Oki, M. and Nishimoto, T. 2000. J Biol Chem. 275: 32894-900. PMID: 10921930
4. Fission yeast Mog1p homologue, which interacts with the small GTPase Ran, is required for mitosis-to-interphase transition and poly(A)(+) RNA metabolism.  |  Tatebayashi, K., et al. 2001. Genetics. 157: 1513-22. PMID: 11290708
5. Insights into protein-protein interfaces using a Bayesian network prediction method.  |  Bradford, JR., et al. 2006. J Mol Biol. 362: 365-86. PMID: 16919296
6. Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p.  |  Xu, Q., et al. 2006. Proteins. 65: 777-82. PMID: 16948158
7. Structure-based Epitope Mapping of Mycobacterium tuberculosis Secretary Antigen MTC28.  |  Kundu, P., et al. 2016. J Biol Chem. 291: 13943-13954. PMID: 27189947
8. The structure of DcrB, a lipoprotein from Salmonella enterica, reveals flexibility in the N-terminal segment of the Mog1p/PsbP-like fold.  |  Rasmussen, DM., et al. 2018. J Struct Biol. 204: 513-518. PMID: 30339832
9. The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure.  |  Feiler, CG., et al. 2020. Acta Crystallogr F Struct Biol Commun. 76: 609-615. PMID: 33263573
10. Mog1 deficiency promotes cardiac contractile dysfunction and isoproterenol-induced arrhythmias associated with cardiac fibrosis and Cx43 remodeling.  |  Zhao, M., et al. 2022. Biochim Biophys Acta Mol Basis Dis. 1868: 166429. PMID: 35533905

The preferred Mog1p antibody is Mog1p Antibody (F-8): sc-398128.