MNDA Antibody (C-3): sc-390739
- MNDA Antibody (C-3) is a mouse monoclonal IgG1 κ MNDA antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 372-407 of MNDA of human origin
- MNDA Antibody (C-3) is recommended for detection of MNDA of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MNDA Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MNDA Antibody (C-3) for WB and IHC(P) applications. These reagents are now offered in bundles with MNDA Antibody (C-3) (see ordering information below).
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MNDA Antibody (C-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects MNDA protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MNDA (C-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MNDA protein, or myeloid cell nuclear differentiation antigen, plays a crucial role in immune response, particularly in differentiation and function of myeloid cells, which are essential for innate immunity. MNDA primarily localizes in the nucleus, where MNDA (C-3) monoclonal antibody detects regulation of gene expression and modulation of transcription factors such as NFkB, E2F, AP-1, and p53. This nuclear localization enables direct influence on cellular processes such as proliferation and apoptosis, impacting overall immune response. MNDA protein interacts with other interferon-inducible proteins, including IFI-16, underscoring importance in immune regulation. Expression of MNDA specifically occurs in cells of granulocyte-macrophage lineage, highlighting significance in development and function of these critical immune cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MNDA Antibody (C-3) References:
- The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. | Briggs, RC., et al. 1994. Blood. 83: 2153-62. PMID: 7512843
- IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. | Dawson, MJ. and Trapani, JA. 1995. J Cell Biochem. 57: 39-51. PMID: 7536752
- A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes. | Tannenbaum, CS., et al. 1993. J Leukoc Biol. 53: 563-8. PMID: 7684766
- The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities. | Min, W., et al. 1996. Mol Cell Biol. 16: 359-68. PMID: 8524315
- Characterization of the human myeloid cell nuclear differentiation antigen gene promoter. | Kao, WY., et al. 1996. Biochim Biophys Acta. 1308: 201-4. PMID: 8809111
- Inhibition of E2F-mediated transcription by p202. | Choubey, D., et al. 1996. EMBO J. 15: 5668-78. PMID: 8896460
- p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. | Datta, B., et al. 1996. J Biol Chem. 271: 27544-55. PMID: 8910340
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MNDA Antibody (C-3) | sc-390739 | 200 µg/ml | $316.00 | |||
MNDA Antibody (C-3): m-IgG Fc BP-HRP Bundle | sc-530245 | 200 µg Ab; 10 µg BP | $354.00 | |||
MNDA Antibody (C-3): m-IgGκ BP-HRP Bundle | sc-523659 | 200 µg Ab, 40 µg BP | $354.00 | |||
MNDA Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-543953 | 200 µg Ab; 20 µg BP | $354.00 | |||
MNDA Antibody (C-3) AC | sc-390739 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MNDA Antibody (C-3) HRP | sc-390739 HRP | 200 µg/ml | $316.00 | |||
MNDA Antibody (C-3) FITC | sc-390739 FITC | 200 µg/ml | $330.00 | |||
MNDA Antibody (C-3) PE | sc-390739 PE | 200 µg/ml | $343.00 | |||
MNDA Antibody (C-3) Alexa Fluor® 488 | sc-390739 AF488 | 200 µg/ml | $357.00 | |||
MNDA Antibody (C-3) Alexa Fluor® 546 | sc-390739 AF546 | 200 µg/ml | $357.00 | |||
MNDA Antibody (C-3) Alexa Fluor® 594 | sc-390739 AF594 | 200 µg/ml | $357.00 | |||
MNDA Antibody (C-3) Alexa Fluor® 647 | sc-390739 AF647 | 200 µg/ml | $357.00 | |||
MNDA Antibody (C-3) Alexa Fluor® 680 | sc-390739 AF680 | 200 µg/ml | $357.00 | |||
MNDA Antibody (C-3) Alexa Fluor® 790 | sc-390739 AF790 | 200 µg/ml | $357.00 | |||
MNDA (C-3) Neutralizing Peptide | sc-390739 P | 100 µg/0.5 ml | $68.00 |