MMP9 Antibody (E-11): sc-393859

MMP-9 Antibody (E-11) is a mouse monoclonal IgG2b antibody, recognizing an epitope between amino acids 678-707 at the C-terminus of human MMP-9. Anti-MMP-9 antibody (E-11) detects MMP-9 from mouse, rat, and human origins in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MMP-9, a member of the matrix metalloproteinase (MMP) family, plays a critical role in the degradation of extracellular matrix components like collagen, fibronectin, and laminin, which is vital for processes like tissue remodeling and inflammation. MMP-9 interacts with several key proteins that modulate its function, including tissue inhibitors of metalloproteinases (TIMPs), particularly TIMP-1, which binds to the catalytic domain of MMP-9, inhibiting its proteolytic activity. MMP-9 also works in conjunction with MMP-2 in the breakdown of type IV collagen in the basement membrane, contributing to processes like angiogenesis and tumor metastasis. Additionally, MMP-9 interacts with integrins and CD44, which can facilitate its localization to the cell surface and regulate cell migration. Dysregulation of MMP-9 has been implicated in various pathological conditions, making MMP-9 a target for studying extracellular matrix turnover and cellular dynamics. MMP-9 (E-11) antibody is an essential tool for investigating MMP-9′s role in extracellular matrix degradation and related cellular processes across multiple species.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MMP9 Antibody (E-11) has 166 citations in a variety of scientific publications.

Primary antibodies like Anti-MMP9 Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MMP9 Antibody (E-11) Specifications

Alternate Product Name: MMP-9

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids: 678-707

Epitope Target: MMP-9

Epitope Species: human

Product Reactivity/Detection: MMP-9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 166 citations in various scientific publications

Available Conjugates/Forms for MMP9 Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred MMP9 antibody is MMP9 Antibody (2C3): sc-21733.