MMP-13 Antibody (MM0019-12E10): sc-101564

MMP-13 Antibody (MM0019-12E10) is a mouse monoclonal IgG1 antibody engineered to detect matrix metalloproteinase-13 (MMP-13), also known as collagenase-3, with exceptional accuracy in western blotting (WB), immunofluorescence (IF), and immunohistochemistry applications. Raised against recombinant human MMP-13, MMP-13 antibody (MM0019-12E10) exclusively recognizes MMP-13 from human sources, ensuring no cross-reactivity with other members of the matrix metalloproteinase family, which guarantees precise and reliable results for your research. MMP-13 is a crucial enzyme located in the extracellular matrix, where MMP-13 plays a vital role in the degradation of collagen types I, II, and III, facilitating essential processes such as fetal bone development and adult bone remodeling. Beyond physiological functions, MMP-13 is significantly involved in pathological conditions like cancer metastasis and osteoarthritis, where MMP-13 contributes to the breakdown of extracellular matrix components, promoting tumor invasion and joint degradation. Understanding the expression and regulation of MMP-13 is essential for developing targeted therapies aimed at mitigating these diseases. By enabling accurate detection and localization of MMP-13, anti-MMP-13 antibody (MM0019-12E10) supports advanced studies into the mechanisms of tissue remodeling and the pathological progression of various conditions. Available in a non-conjugated form, MMP-13 monoclonal antibody (MM0019-12E10) provides versatility for conjugation with different labels to suit specific experimental requirements.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MMP-13 Antibody (MM0019-12E10) References:

1. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.  |  Freije, JM., et al. 1994. J Biol Chem. 269: 16766-73. PMID: 8207000
2. Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.  |  Reinemer, P., et al. 1994. FEBS Lett. 338: 227-33. PMID: 8307185
3. Matrix metalloproteinases: a review.  |  Birkedal-Hansen, H., et al. 1993. Crit Rev Oral Biol Med. 4: 197-250. PMID: 8435466
4. Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development.  |  Johansson, N., et al. 1997. Dev Dyn. 208: 387-97. PMID: 9056642
5. Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis.  |  Ståhle-Bäckdahl, M., et al. 1997. Lab Invest. 76: 717-28. PMID: 9166290
6. Expression of several matrix metalloproteinase genes in human monocytic cells.  |  Machein, U. and Conca, W. 1997. Adv Exp Med Biol. 421: 247-51. PMID: 9330704

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MMP-13 Antibody (MM0019-12E10) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-MMP-13 Antibody (MM0019-12E10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MMP-13 Antibody (MM0019-12E10) Specifications

Alternate Product Name: MMP-13

Product Clone Name: MM0019-12E10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: MMP-13

Epitope Species: human

Product Reactivity/Detection: MMP-13

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for MMP-13 Antibody (MM0019-12E10): N/A

The preferred MMP-13 antibody is MMP-13 Antibody (C-3): sc-515284.