Mig-6 Antibody (D-4): sc-390905
- Mig-6 Antibody (D-4) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 227-253 within an internal region of Mig-6 of human origin
- recommended for detection of Mig-6 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and bovine
- See Mig-6 (D-1): sc-137154 for Mig-6 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mig-6 Antibody (D-4). This work is in progress.
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Mig-6 Antibody (D-4) is a mouse monoclonal IgG2a antibody that detects Mig-6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mig-6, also known as Gene 33 or RALT, is a crucial cytoplasmic protein that plays a significant role as a feedback inhibitor of the ErbB-2 mitogenic function, thereby suppressing oncogenic activity. Mig-6 binds to the epidermal growth factor receptor (EGFR) upon EGF stimulation, acting as a negative feedback regulator and potentially serving as a tumor suppressor. Additionally, Mig-6 is involved in the transcriptional activation of NFκB by interacting with inhibitor IκB-α, which is vital for cellular responses to chronic stress. Mig-6 expression is notably upregulated during cell growth and in response to various stressors, including diabetic nephropathy and mechanical strain, highlighting a role in cellular adaptation and survival. Mig-6 is predominantly expressed in the liver, placenta, and lung, making anti-Mig-6 antibody (D-4) an essential tool for researchers studying functions and implications in various biological processes and diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Mig-6 Antibody (D-4) References:
- Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling. | Li, Z., et al. 2012. Mol Carcinog. 51: 522-34. PMID: 21739478
- Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation. | Zhang, YW., et al. 2012. PLoS One. 7: e38955. PMID: 22701735
- Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. | Staal, B., et al. 2014. Proc Natl Acad Sci U S A. 111: 2590-5. PMID: 24550287
- Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling. | Yoo, JY., et al. 2015. Biochem Biophys Res Commun. 462: 409-14. PMID: 25976672
- Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF. | Jiang, X., et al. 2016. Oncotarget. 7: 49180-49193. PMID: 27341132
- Mig-6 is down-regulated in HCC and inhibits the proliferation of HCC cells via the P-ERK/Cyclin D1 pathway. | Li, Z., et al. 2017. Exp Mol Pathol. 102: 492-499. PMID: 28506767
- Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis. | Liu, J., et al. 2017. Lung Cancer. 112: 47-56. PMID: 29191600
- MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT. | Yoo, JY., et al. 2018. BMC Cancer. 18: 605. PMID: 29843645
- AAV-Mig-6 Increase the Efficacy of TAE in VX2 Rabbit Model, Is Associated With JNK Mediated Autophagy. | Li, Z., et al. 2019. J Cancer. 10: 1060-1069. PMID: 30854112
- Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma. | Kang, DH., et al. 2020. BMC Cancer. 20: 571. PMID: 32552717
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mig-6 Antibody (D-4) | sc-390905 | 200 µg/ml | $322.00 | |||
Mig-6 (D-4) Neutralizing Peptide | sc-390905 P | 100 µg/0.5 ml | $69.00 |