Mig-6 Antibody (D-12): sc-137155

Mig-6 Antibody (D-12) is a mouse monoclonal IgG1 antibody that detects Mig-6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mig-6, also known as Gene 33 or RALT, is a crucial cytoplasmic protein that plays a significant role in cellular signaling by acting as a feedback inhibitor of the ErbB-2 receptor′s mitogenic functions, thereby suppressing oncogenic activity. Mig-6′s importance lies in regulating the epidermal growth factor receptor (EGFR) signaling pathway; upon stimulation by epidermal growth factor (EGF), Mig-6 binds to EGFR and serves as a negative feedback regulator, which is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation. Additionally, Mig-6 is involved in transcriptional activation of NFκB by interacting with inhibitor IκB-α, allowing cells to adapt to chronic stress conditions. Mig-6 expression is notably upregulated in response to various stressors, including diabetic nephropathy and mechanical strain, and is predominantly found in tissues such as liver, placenta, and lung. With multifaceted roles in cellular regulation and stress response, Mig-6 remains a protein of great interest in cancer research and therapeutic development, making anti-Mig-6 antibody (D-12) an essential tool for researchers studying these pathways.

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Mig-6 Antibody (D-12) References:

1. Mig-6 gene knockout induces neointimal hyperplasia in the vascular smooth muscle cell.  |  Lee, JH., et al. 2014. Dis Markers. 2014: 549054. PMID: 25574067
2. MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells.  |  Yoo, JY., et al. 2018. Oncogene. 37: 255-262. PMID: 28925396
3. Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice.  |  Bellini, M., et al. 2020. Arthritis Res Ther. 22: 119. PMID: 32430054
4. MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer.  |  He, J., et al. 2021. EMBO Rep. 22: e50781. PMID: 33655623
5. Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue.  |  Choung, S., et al. 2021. Biochem Biophys Res Commun. 572: 92-97. PMID: 34358969
6. Mig-6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma.  |  Cui, Y., et al. 2022. Thorac Cancer. 13: 54-60. PMID: 34845855
7. Mig-6 Inhibits Autophagy in HCC Cell Lines by Modulating miR-193a-3p.  |  Qu, L., et al. 2022. Int J Med Sci. 19: 338-351. PMID: 35165519
8. Hypermethylation of Mig-6 gene promoter region inactivates its function, leading to EGFR/ERK signaling hyperphosphorylation, and is involved in arsenite-induced hepatic stellate cells activation and extracellular matrix deposition.  |  Wang, D., et al. 2022. J Hazard Mater. 439: 129577. PMID: 35850069
9. MIG-6 Is Critical for Progesterone Responsiveness in Human Complex Atypical Hyperplasia and Early-Stage Endometrial Cancer.  |  Jeong, O., et al. 2022. Int J Mol Sci. 23: PMID: 36498921
10. Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation.  |  Wick, M., et al. 1995. Exp Cell Res. 219: 527-35. PMID: 7641805

The preferred Mig-6 antibody is Mig-6 Antibody (D-1): sc-137154.